Biomedical sciences publications
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Epithelial Responses in Radiation-Induced Lung Injury (RILI) Allow Chronic Inflammation and Fibrogenesis
We took an unbiased approach through RNA sequencing to determine the in vivo response of the lung epithelium in the progression of RIPF. In our methodology, we isolated CD326+ epithelium…
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Stress, hypothalamic pituitary adrenal axis activity and autonomic nervous system function in adolescents with insomnia
We investigated the relationship between insomnia, stress, hypothalamic-pituitary-adrenal (HPA) axis activity, and autonomic nervous system (ANS) function in adolescence.
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Call to action: an open-source pipeline for standardized performance evaluation of sleep-tracking technology
There is an urgent need for standardized, rigorous, and open-source tools that the community can access in a timely manner to systematically evaluate the performance of new technology for measuring…
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Multi-atlas thalamic nuclei segmentation on standard T1-weighed MRI with application to normal aging
The threefold aims of this study were to validate the use of a modified thalamic nuclei segmentation method on standard T1 MRI data, to apply this method to quantify age-related…
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A prospective study revealing a compounded burden of COVID-19, sex, and clinical diagnosis of alcohol use disorder and HIV infection on quality of life, anxiety, and alcohol use
Participants were drawn from our ongoing longitudinal studies of people with HIV infection, alcohol use disorder (AUD), HIV + AUD comorbidity, and controls.
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Postural instability in HIV infection: relation to central and peripheral nervous system markers
Our objective is to determine the independent contributions of central nervous system (CNS) and peripheral nervous system (PNS) metrics to balance instability in people with HIV (PWH) compared with people…
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Prior test experience confounds longitudinal tracking of adolescent cognitive and motor development
We measured change in cognitive and motor abilities over four test sessions in participants from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study.
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Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice
We evaluated the efficacy of two small molecule hypocretin/orexin receptor-2 (HCRTR2) agonists in narcoleptic male orexin/tTA; TetO-DTA mice.
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Assessment of Immunologically Potent Carbohydrates
We present here our laboratory protocols for performing carbohydrate ELISA and discuss several assay platforms that may be applied complementarily to explore the carbohydrate moieties that are critical for host…
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It’s Not Just About the Hot Flashes: Menopausal Hormone Changes and Disrupted Sleep
Sleep disturbances are common during the menopausal transition, being reported by more than half of midlife women.
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Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach
In this study, adolescents from the NCANDA study who endorsed little to no alcohol use at baseline were assessed with structural magnetic resonance imaging and followed longitudinally at four yearly…
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Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin
Here we optimize our lead peptide by a series of chemical modifications including truncations, N-terminal capping, and changes in valency.