Biomedical sciences publications
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Sleep, brain systems, and persistent stress in early adolescents during COVID-19: Insights from the ABCD study
Here, we analyzed clusters of perceived stress levels across the pandemic and determined developmentally relevant pre-pandemic risk factors in brain structure and sleep of persistently high stress during the first…
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Frontal cortical volume deficits as enduring evidence of childhood abuse in community adults with AUD and HIV infection comorbidity
Here, we examined the neural and behavioral correlates of childhood trauma history in alcohol use disorder (AUD), HIV infection (HIV), and their comorbidity (AUD+HIV).
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Contributions of Cerebral White Matter Hyperintensities to Postural Instability in Aging With and Without Alcohol Use Disorder
Both postural instability and brain white matter hyperintensities (WMHs) are noted markers of normal aging and alcohol use disorder (AUD). Here, we questioned what variables contribute to the sway path–WMH…
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Deficiency of orexin signaling during sleep is involved in abnormal REM sleep architecture in narcolepsy
Here, we determined the activity dynamics of orexin neurons during sleep that suppress the abnormal REM sleep architecture of narcolepsy.
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Identification and characterization of screen use trajectories from late childhood to adolescence in a US-population based cohort study
This study will identify and characterize the subgroups of adolescents sharing similar trajectories of screen use from childhood to adolescence.
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Biological sex influences sleep phenotype in mice experiencing spontaneous opioid withdrawal
We describe here a model of opioid withdrawal in mice that resembles the sleep phenotype characteristic of withdrawal in humans.
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Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone
Male contraceptive development has included use of testosterone (T) with or without a progestin or the use of a single molecule such as progestogenic androgens (PA) for suppression of testicular…
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Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples
This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use...
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Higher blood pressure and weight observed among early adolescents during the COVID-19 pandemic
The aim of this study is to quantify differences in blood pressure and weight before and during the COVID-19 pandemic among a demographically diverse national sample of early adolescents.
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The Menstrual Cycle and Sleep
Although objective sleep continuity remains unchanged across the regular, asymptomatic menstrual cycle, activity in the sleep electroencephalogram varies.
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Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/near MC4R Gene with Obesity-Related Biomarkers in a Spanish Pediatric Cohort
Our results highlight that metabolic risk factors, especially alterations in carbohydrate metabolism, were related to rs17782313.
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Evaluation of a device-agnostic approach to predict sleep from raw accelerometry data collected by Apple Watch Series 7, Garmin Vivoactive 4, and ActiGraph GT9X Link in children with sleep disruptions
This study demonstrates that raw acceleration data from consumer wearable devices has the potential to be harnessed to predict sleep in children.