Biomedical sciences publications
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Monkeys That Voluntarily and Chronically Drink Alcohol Damage Their Brains: A Longitudinal MRI Study
Here we report monkey oral ethanol self-administration combined with MR imaging to characterize brain changes over 15 months in 18 well-nourished rhesus macaques.
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Microdroplet Temperature Calibration Via Thermal Dissociation of Quenched DNA Oligomers
Here, we present a novel method for calibrating the temperature of microdroplets using quenched, fluorescently labeled DNA oligomers.
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Hyperpolarized [1,4-C-13]-Diethylsuccinate: A Potential Dnp Substrate for in Vivo Metabolic Imaging
In this work, the applicability of a novel imaging agent, [1,4-(13)C]-diethylsuccinate, for hyperpolarized (13)C metabolic imaging of the TCA cycle was explored.
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PORTR: Pre-Operative and Post-Recurrence Brain Tumor Registration
We propose a new method for deformable registration of pre-operative and post-recurrence brain MR scans of glioma patients. To address this challenging task, our method, called PORTR, explicitly accounts for…
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Type IV Collagen α1-Chain Noncollagenous Domain Blocks MMP-2 Activation Both in-Vitro and in-Vivo
In the present study, the regulation of MMP-2 activation by α1(IV)NC1 was evaluated. α1β1-integrin which is required for inhibition of angiogenesis is not playing a role in cellular invasion and inhibition of…
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Mechanism of Action of Flufirvitide, a Peptide Inhibitor of Influenza Virus Infection
Influenza is an infectious disease typically transmitted through the air. It is responsible for seasonal epidemics affecting millions of people, and sporadic global pandemics. Influenza infection is a membrane fusion‐dependant process, occurring…
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Neuroinflammation and Alpha-Synuclein Accumulation in Response to Glucocerebrosidase Deficiency Are Accompanied by Synaptic Dysfunction
In this report we describe and characterize two novel long-lived transgenic mouse models of Gba deficiency, along with a subchronic conduritol-ß-epoxide (CBE) exposure paradigm.
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[1-125]AT-1012, a New High Affinity Radioligand for the α3β4 Nicotinic Acetylcholine Receptors
We report here the vitro characterization of this radioligand in receptor binding and in vitro autoradiographic studies targeting the α3β4* nAChR.
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Evaluating the Toxicity of Novel Zn-DTPA Tablet Formulation in Dogs and Rats
The purpose of this research work is to evaluate toxicity of diethylenetriamine pentaacetic acid zinc trisodium salt (Zn-DTPA) tablets.
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Reduced Quality of Life When Experiencing Menstrual Pain in Women with Primary Dysmenorrhea
We investigated whether QoL varies between women with and without severe primary dysmenorrhea, and whether QoL is impaired only during menstruation or also during pain-free phases of the menstrual cycle.
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HPLC Method Development, Validation and Impurity Characterization for an Antitumor Hsp90 Inhibitor-PU-H71 (NSC 750424)
An HPLC method for the assay of the heat shock protein 90 inhibitor, PU-H71 (NSC 750424), has been developed and validated.
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Glyco-Epitope Diversity: An Evolving Area of Glycomics Research and Biomarker Discovery
Tumor glycomics research in recent years has uncovered a large panel of tumor-associated carbohydrate antigens and evidence of immune recognition of tumor-derived aberrant carbohydrates.