Biomedical sciences publications
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Neuroinflammation and Alpha-Synuclein Accumulation in Response to Glucocerebrosidase Deficiency Are Accompanied by Synaptic Dysfunction
In this report we describe and characterize two novel long-lived transgenic mouse models of Gba deficiency, along with a subchronic conduritol-ß-epoxide (CBE) exposure paradigm.
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[1-125]AT-1012, a New High Affinity Radioligand for the α3β4 Nicotinic Acetylcholine Receptors
We report here the vitro characterization of this radioligand in receptor binding and in vitro autoradiographic studies targeting the α3β4* nAChR.
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Evaluating the Toxicity of Novel Zn-DTPA Tablet Formulation in Dogs and Rats
The purpose of this research work is to evaluate toxicity of diethylenetriamine pentaacetic acid zinc trisodium salt (Zn-DTPA) tablets.
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Reduced Quality of Life When Experiencing Menstrual Pain in Women with Primary Dysmenorrhea
We investigated whether QoL varies between women with and without severe primary dysmenorrhea, and whether QoL is impaired only during menstruation or also during pain-free phases of the menstrual cycle.
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HPLC Method Development, Validation and Impurity Characterization for an Antitumor Hsp90 Inhibitor-PU-H71 (NSC 750424)
An HPLC method for the assay of the heat shock protein 90 inhibitor, PU-H71 (NSC 750424), has been developed and validated.
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Biomarkers in Pharmacology and Drug Discovery
The relative utility of single biomarkers compared to biomarker panels is discussed, along with paradigms for biomarker development, the latter in the context of three large-scale biomarker consortia, the Critical…
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Comparative Molecular Field Analysis of Fenoterol Derivatives Interacting with an Agonist-Stabilized Form of the β(2)-Adrenergic Receptor
The β2-adrenergic receptor (β2-AR) agonist [3H]-(R,R′)-methoxyfenoterol was employed as the marker ligand in displacement studies measuring the binding affinities (Ki values) of the stereoisomers of a series of 4′-methoxyfenoterol analogs in…
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Design of a Serum Stability Tag for Bioactive Peptides
Here we explored a possibility of designing a serum stability tag made of natural amino acids. We observed that a diproline motif (-Pro-Pro-) shows remarkable stability against serum endopeptidases.
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The Hypocretin/Orexin Antagonist Almorexant Promotes Sleep without Impairment of Performance in Rats
To test the hypothesis that less functional impairment results from HcrtR antagonist-induced sleep, we evaluated the performance of rats in the Morris Water Maze in the presence of ALM vs.…
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Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism
Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence.
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A Tailoring Algorithm to Optimize Behavior Change
A new algorithm, developed with data from smoking cessation clinical trials and published practice guidelines, is designed to predict the likelihood of abstinence.
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Gene-Environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson’s Disease
Here we describe the use of a neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which produces a nigrostriatal lesion to elucidate the distinct contributions of LOX isozymes to neurodegeneration related to PD.