Biomedical sciences publications
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Biological Barriers and Current Strategies for Modifying Nanoparticle Bioavailability
This paper reviews the anatomy of the primary organs (kidney, liver, and spleen) responsible for nanoparticle bioelimination and the components of the innate immune system (complement system and scavenger receptors)…
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Biomarkers in Pharmacology and Drug Discovery
The relative utility of single biomarkers compared to biomarker panels is discussed, along with paradigms for biomarker development, the latter in the context of three large-scale biomarker consortia, the Critical…
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Comparative Molecular Field Analysis of Fenoterol Derivatives Interacting with an Agonist-Stabilized Form of the Ī²(2)-Adrenergic Receptor
The Ī²2-adrenergic receptor (Ī²2-AR) agonist [3H]-(R,Rā²)-methoxyfenoterol was employed as the marker ligand in displacement studies measuring the binding affinities (KiĀ values) of the stereoisomers of a series of 4ā²-methoxyfenoterol analogs in…
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Extra Cellular Matrix Derived Metabolite Regulates Angiogenesis by FasL Mediated Apoptosis
In this current study the antiangiogenic and pro-apoptotic actions of Ī±1(IV)NC1 and its N- and C- peptides Ī±1S1(IV)NC1, Ī±1S2(IV)NC1 were investigatedĀ in-vitroĀ andĀ in-vivo.
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A Role for Cortical nNOS/NK1 Neurons in Coupling Homeostatic Sleep Drive to EEG Slow Wave Activity
These findings support the hypothesis that cortical nNOS/NK1 neurons translate homeostatic sleep drive into up-regulation of NREM Ī“ power through an NO-dependent mechanism.
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Rapid Identification of Sequences for Orphan Enzymes to Power Accurate Protein Annotation
In this study, we demonstrate how this orphan enzyme āback catalogā is a fertile source for rapidly advancing the state of protein annotation.
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Influence of a Dopamine Pathway Additive Genetic Efficacy Score on Smoking Cessation: Results from Two Randomized Clinical Trials of Bupropion
We aimed to evaluate associations of treatment and an āadditive genetic efficacy scoreā (AGES) based on dopamine functional polymorphisms with time to first smoking lapse and point prevalence abstinence at…
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Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated with Onset of Regular Smoking
This meta-analysis examines early smoking phenotypes and SNPs in the gene cluster to determine: (1) whether the most robust association signal in this region (rs16969968) for other smoking behaviors is…
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In Vivo Investigation of Cardiac Metabolism in the Rat Using MRS of Hyperpolarized [1-C-13] and [2-C-13]Pyruvate
This work investigates changes in the metabolic fate of acetyl-CoA in response to metabolic interventions of DCA-induced increased PDC flux in the fed and fasted state, and increased cardiac workload…
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A Regression Model for Risk Difference Estimation in Population-Based Case-Control Studies Clarifies Gender Differences in Lung Cancer Risk of Smokers and Never Smokers
Additive risk models are necessary for understanding the joint effects of exposures on individual and population disease risk. Yet technical challenges have limited the consideration of additive risk models in…
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Formulation Development of Acyclovir/Tenofovir Loaded Two-Polymer (SR-2P) Bioadhesive Vaginal Gel
The in vitro release of drugs from the optimized gelĀ formulation in simulated vaginal fluid was characterized using in-line Franz diffusion cell with regenerated celluloseĀ membrane.
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Microinjections of the Hypocretin Antagonist Almorexant Vs. Gabaergic Agonist Zolpidem in Basal Forebrain Show Differential Effects on Cortical Adenosine Levels in Freely-Moving Rats
We used in vivo microdialysis and HPLC analysis to examine cortical adenosine (ADO) levels following BF microinjections of ZOL (0.6 Āµg/0.2 Āµl), ALM (1.0 Āµg/0.2 Āµl), or VEH (aCSF) combined…