Biomedical sciences publications
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Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism
Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence.
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A Tailoring Algorithm to Optimize Behavior Change
A new algorithm, developed with data from smoking cessation clinical trials and published practice guidelines, is designed to predict the likelihood of abstinence.
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Gene-Environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson’s Disease
Here we describe the use of a neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which produces a nigrostriatal lesion to elucidate the distinct contributions of LOX isozymes to neurodegeneration related to PD.
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Influence of a Dopamine Pathway Additive Genetic Efficacy Score on Smoking Cessation: Results from Two Randomized Clinical Trials of Bupropion
We aimed to evaluate associations of treatment and an ‘additive genetic efficacy score’ (AGES) based on dopamine functional polymorphisms with time to first smoking lapse and point prevalence abstinence at…
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Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated with Onset of Regular Smoking
This meta-analysis examines early smoking phenotypes and SNPs in the gene cluster to determine: (1) whether the most robust association signal in this region (rs16969968) for other smoking behaviors is…
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In Vivo Investigation of Cardiac Metabolism in the Rat Using MRS of Hyperpolarized [1-C-13] and [2-C-13]Pyruvate
This work investigates changes in the metabolic fate of acetyl-CoA in response to metabolic interventions of DCA-induced increased PDC flux in the fed and fasted state, and increased cardiac workload…
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Extra Cellular Matrix Derived Metabolite Regulates Angiogenesis by FasL Mediated Apoptosis
In this current study the antiangiogenic and pro-apoptotic actions of α1(IV)NC1 and its N- and C- peptides α1S1(IV)NC1, α1S2(IV)NC1 were investigated in-vitro and in-vivo.
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A Role for Cortical nNOS/NK1 Neurons in Coupling Homeostatic Sleep Drive to EEG Slow Wave Activity
These findings support the hypothesis that cortical nNOS/NK1 neurons translate homeostatic sleep drive into up-regulation of NREM δ power through an NO-dependent mechanism.
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Rapid Identification of Sequences for Orphan Enzymes to Power Accurate Protein Annotation
In this study, we demonstrate how this orphan enzyme “back catalog” is a fertile source for rapidly advancing the state of protein annotation.
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Vagal Withdrawal During Hot Flashes Occurring in Undisturbed Sleep
Little is known about the impact of hot flashes on cardiac autonomic regulation, in particular vagal control. Thereby, we assessed the cardiac autonomic profile associated with physiological hot flashes occurring…
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Zolpidem Impairs Attention/Motivation in the Rodent Psychomotor Vigilance Task More Than Almorexant
Here, we tested the effects of ALM and ZOL on the Rodent Psychomotor Vigilance Task (rPVT), a sensitive test of attention and motivation. These results are consistent with the hypothesis…
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Exchange-Linked Dissolution Agents in Dissolution-DNP C-13 Metabolic Imaging
The use of unlabeled exchange-linked dissolution agents in hyperpolarized metabolic imaging was studied to examine pool size limits and saturation relative to the availability of NADH.