Biomedical sciences publications
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Consideration of Species Differences in Developing Novel Molecules as Cognition Enhancers
The issues covered here will aid in task development and utilization across species as well as reinforcing the positive role preclinical research can have in developing procognitive treatments for psychiatric…
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Vagal Withdrawal During Hot Flashes Occurring in Undisturbed Sleep
Little is known about the impact of hot flashes on cardiac autonomic regulation, in particular vagal control. Thereby, we assessed the cardiac autonomic profile associated with physiological hot flashes occurring…
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Zolpidem Impairs Attention/Motivation in the Rodent Psychomotor Vigilance Task More Than Almorexant
Here, we tested the effects of ALM and ZOL on the Rodent Psychomotor Vigilance Task (rPVT), a sensitive test of attention and motivation. These results are consistent with the hypothesis…
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Exchange-Linked Dissolution Agents in Dissolution-DNP C-13 Metabolic Imaging
The use of unlabeled exchange-linked dissolution agents in hyperpolarized metabolic imaging was studied to examine pool size limits and saturation relative to the availability of NADH.
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Long-Term Ethanol Consumption Changes the Expression of Neuronal Nicotinic Receptors – Implications for Treatment Strategies
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High Frequency Neuronal Oscillations in a Cynomologus Macaque Test of Sustained Attention Following Nmda Receptor Antagonism
These studies may help to define the role of high frequency oscillations in cognitive processes in higher order species, and to enhance our understanding of EEG recordings as a translatable…
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Longitudinal Characterization of Diurnal Rhythms of Activity and Core Body Temperature in the zQ175 Knock-in Mouse Model of Huntington’s Disease: Genotype and Sex Interactions
These initial findings demonstrate that mutant huntington expression in this model causes progressive motor and thermoregulatory deficits with significant genotype and sex differences.
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Sleep-Wake Regulation Is Altered in Mice Lacking Trace Amine-Associated Receptor 1
Here, we tested the hypothesis that endogenous TAAR1 tone contributes to the normal regulation of sleep and wakefulness. Abnormal levels of TAs have long been associated with neuropsychiatric disorders; altered…
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AT-202, a Nociceptin Receptor Agonist, Blocks Drug- and Stress-Induced Reinstatement of Extinguished Cocaine Conditioned Place Preference
In the present study we examined the effects of AT-202 on acquisition and drug-primed or stress-induced reinstatement of cocaine CPP. These findings provide preliminary evidence that the NOP receptor agonists…
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Optogenetic Silencing of Hypocretin/Orexin Neurons Using Transgenic Expression of a Light-Driven Proton Pump
Arch may be better suited for long-term circuit inhibition, and may serve as an important tool for deciphering the role of Hcrt signaling in the maintenance of wakefulness.
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Varenicline Markedly Decreases Antipsychotic-Induced Tardive Dyskinesia in a Rodent Model
Tardive dyskinesia is a potentially irreversible drug-induced movement disorder that arises as a side effect of antipsychotic therapy. Antipsychotics form the mainstay of treatment for schizophrenia and bipolar disorder and,…
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Diffustion Tensor Imaging Detects Callosal Fiber Integrity Change over a 1-Year Follow-up in Chronic Alcoholics Who Maintained Sobriety
Here, we investigated change in CC microstructural fiber integrity over one year in 12 (7w, 5m) alcoholics (ALC) and 13 (7w, 6m) age-matched controls (CTL). ALC and CTL did not…