Biomedical sciences publications

Here, we tested the effects of ALM and ZOL on the Rodent Psychomotor Vigilance Task (rPVT), a sensitive test of attention and motivation. These results are consistent with the hypothesis…

The use of unlabeled exchange-linked dissolution agents in hyperpolarized metabolic imaging was studied to examine pool size limits and saturation relative to the availability of NADH.

These studies may help to define the role of high frequency oscillations in cognitive processes in higher order species, and to enhance our understanding of EEG recordings as a translatable…

These initial findings demonstrate that mutant huntington expression in this model causes progressive motor and thermoregulatory deficits with significant genotype and sex differences.

Here, we tested the hypothesis that endogenous TAAR1 tone contributes to the normal regulation of sleep and wakefulness. Abnormal levels of TAs have long been associated with neuropsychiatric disorders; altered…

In the present study we examined the effects of AT-202 on acquisition and drug-primed or stress-induced reinstatement of cocaine CPP. These findings provide preliminary evidence that the NOP receptor agonists…

Arch may be better suited for long-term circuit inhibition, and may serve as an important tool for deciphering the role of Hcrt signaling in the maintenance of wakefulness.

Tardive dyskinesia is a potentially irreversible drug-induced movement disorder that arises as a side effect of antipsychotic therapy. Antipsychotics form the mainstay of treatment for schizophrenia and bipolar disorder and,…

Here, we investigated change in CC microstructural fiber integrity over one year in 12 (7w, 5m) alcoholics (ALC) and 13 (7w, 6m) age-matched controls (CTL). ALC and CTL did not…

To investigate the influence of menstrual cycle phase and the presence of severe premenstrual symptoms on cardiac autonomic control during sleep, we performed heart rate variability (HRV) analysis.