Biomedical sciences publications
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Varenicline Markedly Decreases Antipsychotic-Induced Tardive Dyskinesia in a Rodent Model
Tardive dyskinesia is a potentially irreversible drug-induced movement disorder that arises as a side effect of antipsychotic therapy. Antipsychotics form the mainstay of treatment for schizophrenia and bipolar disorder and,…
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Diffustion Tensor Imaging Detects Callosal Fiber Integrity Change over a 1-Year Follow-up in Chronic Alcoholics Who Maintained Sobriety
Here, we investigated change in CC microstructural fiber integrity over one year in 12 (7w, 5m) alcoholics (ALC) and 13 (7w, 6m) age-matched controls (CTL). ALC and CTL did not…
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Autonomic Regulation across Phases of the Menstrual Cycle and Sleep Stages in Women with Premenstrual Syndrome and Healthy Controls
To investigate the influence of menstrual cycle phase and the presence of severe premenstrual symptoms on cardiac autonomic control during sleep, we performed heart rate variability (HRV) analysis.
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Development of Powder-in-Bottle Formulation of Hydroxyurea with Methylparaben Preservative
The compatibility of hydroxyurea with excipients in closed cap conditions at 30°C/65%RH and 40°C/75%RH storage for up to 6 weeks was also studied.
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A Regression Model for Risk Difference Estimation in Population-Based Case-Control Studies Clarifies Gender Differences in Lung Cancer Risk of Smokers and Never Smokers
Additive risk models are necessary for understanding the joint effects of exposures on individual and population disease risk. Yet technical challenges have limited the consideration of additive risk models in…
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Formulation Development of Acyclovir/Tenofovir Loaded Two-Polymer (SR-2P) Bioadhesive Vaginal Gel
The in vitro release of drugs from the optimized gel formulation in simulated vaginal fluid was characterized using in-line Franz diffusion cell with regenerated cellulose membrane.
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A Selective Insular Perfusion Deficit Contributes to Compromised Salience Network Connectivity in Recovering Alcoholic Men
We propose that attenuated insular CBF is a mechanism underlying compromised connectivity among salience network nodes. This local perfusion deficit in alcoholics has the potential to impair ability to switch…
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Pharmacokinetics and Toxicity of a Neuroprotective Cembranoid
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Working Memory Performance and Cardiovascular Activity in Young Primary Insomniacs
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Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia
We investigated the cell-specific in vivo function of PGE2 signaling through its E-prostanoid 2 (EP2) receptor in murine innate immune responses systemically and in the CNS.
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Measuring Mitochondrial Metabolism in Rat Brain in Vivo Using Mr Spectroscopy of Hyperpolarized [2-C-13]Pyruvate
In this study, single-time-point chemical shift imaging data were acquired from rat brain in vivo. [5-13C]Glutamate, [1-13C]acetylcarnitine and [1-13C]citrate were detected in addition to resonances from [2-13C]Pyr and [2-13C]Lac.
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Nicotinic Receptor Agonists Reduce l-DOPA–Induced Dyskinesias in a Monkey Model of Parkinson’s Disease
Here, we investigated whether nicotinic acetylcholine receptor (nAChR) agonists reduced LIDs in nonhuman primates.