Biomedical sciences publications
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α4β2* and α7 Nicotinic Receptors Play a Role in L-Dopa-Induced Dyskinesias; Studies Using Parkinsonian Knockout Mice
Since α4a5β2 nAChRs are also predominantly on striatal dopamine terminals, these data suggest that drugs targeting α4β2 nAChRs may reduce L-dopa-induced dyskinesias in late stage Parkinson’s disease.
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Consideration of Species Differences in Developing Novel Molecules as Cognition Enhancers
The issues covered here will aid in task development and utilization across species as well as reinforcing the positive role preclinical research can have in developing procognitive treatments for psychiatric…
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Vagal Withdrawal During Hot Flashes Occurring in Undisturbed Sleep
Little is known about the impact of hot flashes on cardiac autonomic regulation, in particular vagal control. Thereby, we assessed the cardiac autonomic profile associated with physiological hot flashes occurring…
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Zolpidem Impairs Attention/Motivation in the Rodent Psychomotor Vigilance Task More Than Almorexant
Here, we tested the effects of ALM and ZOL on the Rodent Psychomotor Vigilance Task (rPVT), a sensitive test of attention and motivation. These results are consistent with the hypothesis…
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Exchange-Linked Dissolution Agents in Dissolution-DNP C-13 Metabolic Imaging
The use of unlabeled exchange-linked dissolution agents in hyperpolarized metabolic imaging was studied to examine pool size limits and saturation relative to the availability of NADH.
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Long-Term Ethanol Consumption Changes the Expression of Neuronal Nicotinic Receptors – Implications for Treatment Strategies
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Comparison of Neutralizing Abilities of Human Monoclonal Antibodies Binding Different Epitopes on Botulinum Neurotoxin A
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Multiple CNS Nicotinic Receptors Mediate L-Dopa-Induced Dyskinesias: Studies with Parkinsonian Nicotinic Receptor Knockout Mice
Accumulating evidence supports the idea that drugs acting at nicotinic acetylcholine receptors (nAChRs) may be beneficial for Parkinson's disease.
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Effects of Isoflurane Anesthesia on Hyperpolarized C-13 Metabolic Measurements in Rat Brain
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Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry
To provide an unprecedented understanding of NK cell repertoire diversity, we used mass cytometry to simultaneously analyze 37 parameters, including 28 NK cell receptors, on peripheral blood NK cells from…
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Quantitative LC-MS/MS Analysis of Seven Ginsenosides and Three Aconitum Alkaloids in Shen-Fu Decoction
We successfully developed a rapid resolution liquid chromatography coupled with tandem mass spectrometry (RRLC-MS/MS) method for the simultaneous analysis of seven ginsenosides and three aconitum alkaloids in Shen-Fu decoction, the…
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Women with Dysmenorrhea Are Hypersensitive to Experimental Deep Muscle Pain across the Menstrual Cycle
We investigated whether women with primary dysmenorrhea are hyperalgesic to deep muscle pain induced by a cleanly nociceptive method of hypertonic saline injection.