Biomedical sciences publications
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Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia
We investigated the cell-specific in vivo function of PGE2 signaling through its E-prostanoid 2 (EP2) receptor in murine innate immune responses systemically and in the CNS.
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Measuring Mitochondrial Metabolism in Rat Brain in Vivo Using Mr Spectroscopy of Hyperpolarized [2-C-13]Pyruvate
In this study, single-time-point chemical shift imaging data were acquired from rat brain in vivo. [5-13C]Glutamate, [1-13C]acetylcarnitine and [1-13C]citrate were detected in addition to resonances from [2-13C]Pyr and [2-13C]Lac.
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Nicotinic Receptor Agonists Reduce l-DOPA–Induced Dyskinesias in a Monkey Model of Parkinson’s Disease
Here, we investigated whether nicotinic acetylcholine receptor (nAChR) agonists reduced LIDs in nonhuman primates.
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Comparison of Neutralizing Abilities of Human Monoclonal Antibodies Binding Different Epitopes on Botulinum Neurotoxin A
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Multiple CNS Nicotinic Receptors Mediate L-Dopa-Induced Dyskinesias: Studies with Parkinsonian Nicotinic Receptor Knockout Mice
Accumulating evidence supports the idea that drugs acting at nicotinic acetylcholine receptors (nAChRs) may be beneficial for Parkinson's disease.
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Effects of Isoflurane Anesthesia on Hyperpolarized C-13 Metabolic Measurements in Rat Brain
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Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry
To provide an unprecedented understanding of NK cell repertoire diversity, we used mass cytometry to simultaneously analyze 37 parameters, including 28 NK cell receptors, on peripheral blood NK cells from…
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Quantitative LC-MS/MS Analysis of Seven Ginsenosides and Three Aconitum Alkaloids in Shen-Fu Decoction
We successfully developed a rapid resolution liquid chromatography coupled with tandem mass spectrometry (RRLC-MS/MS) method for the simultaneous analysis of seven ginsenosides and three aconitum alkaloids in Shen-Fu decoction, the…
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Women with Dysmenorrhea Are Hypersensitive to Experimental Deep Muscle Pain across the Menstrual Cycle
We investigated whether women with primary dysmenorrhea are hyperalgesic to deep muscle pain induced by a cleanly nociceptive method of hypertonic saline injection.
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Environmental Levels of Bisphenol-A Can Expand Numbers of Mammary Stem Cells and Potentially Increase Breast Cancer Risk
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Nicotine Reduces Established Levodopa-Induced Dyskinesias in a Monkey Model of Parkinson’s Disease
The goal of this study was to determine whether the duration of nicotine administration affects its ability to reduce LIDs in levodopa-primed and levadopa-naíve monkeys and also to test whether…
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Microglial Beclin 1regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease
Here we show that the autophagy protein beclin 1 is required for efficient phagocytosis in vitro and in mouse brains. Interestingly, microglia isolated from human Alzheimer’s disease (AD) brains show significantly…