Biomedical sciences publications
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Cardiovascular Down-Regulation in Essential Hypotension: Relationships with Autonomic Control and Sleep
In this work, we aimed to clarify the autonomic involvement in the cardiovascular down-regulation in essential hypotension.
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Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
To interrogate B7-H4 expression on tumor cells, we analyzed fresh primary ovarian cancer cells collected from patient ascites and solid tumors, and established cell lines before and after in vivo…
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The Solar Orbiter Imager (SoloHI) Instrument for the Solar Orbiter Mission
We present the design and pre-launch performance of the Solar Orbiter Heliospheric Imager (SoloHI) which is an instrument prepared for inclusion in the ESA/NASA Solar Orbiter mission, currently scheduled for…
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Prolyl Endopeptidase Activity in Bronchoalveolar Lavage Fluid: A Novel Diagnostic Biomarker in a Guinea Pig Model of Invasive Pulmonary Aspergillosis
We are investigating secreted fungal proteases as novel biomarkers for the diagnosis of invasive pulmonary aspergillosis.
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Blocking the B7-H4 Pathway with Novel Recombinant Antibodies Enhances T Cell-Mediated Antitumor Responses
We have recently demonstrated that the expression of B7-H4 on the surface of malignant cells in vivo is inducible, and that novel anti-B7-H4 recombinant antibodies can reverse the inhibition of…
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In Situ Spectrophotometric Measurement of Dissolved Inorganic Carbon in Seawater
SEAS-DIC is a new in situ instrument designed to provide calibrated, high-frequency, long-term measurements of DIC in marine and fresh waters. This instrument, the first spectrophotometric system capable of automated…
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Alpha4beta2 Nicotinic Receptors Play a Role in the nAChR-Mediated Decline in l-Dopa-Induced Dyskinesias in Parkinsonian Rats
The present experiments were done to determine if alpha4beta2* nAChRs are also involved in l-dopa-induced dyskinesias. Since alpha4alpha5beta2 nAChRs are also predominantly on striatal dopamine terminals, these data suggest that…
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Animal Care Practices in Experiments on Biological Rhythms and Sleep: Report of the Joint Task Force of the Society for Research on Biological Rhythms and the Sleep Research Society
This report reviews requirements for experiments on biological rhythms and sleep and discusses how scientific considerations can be reconciled with the recommendations of the Guide.
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Potential Reporting Bias in fMRI Studies of the Brain
Functional magnetic resonance imaging (fMRI) studies have reported multiple activation foci associated with a variety of conditions, stimuli or tasks.
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Carbon-14 Labeling of K777
The antitrypanosomal agent K777•HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease.
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First Measurement of the BO B2Σ+ Radiative Lifetime by Laser-Induced Fluorescence Via the B2Σ+–X2Σ+ Transition
Observation of the temporal evolution of the fluorescence following laser excitation of boron monoxide molecules to the B 2Σ+ state is used to extract the radiative lifetime and collisional removal rate constant with…
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Longitudinal Analysis of the Electroencephalogram and Sleep Phenotype in the R6/2 Mouse Model of Huntington’s Disease
We conducted a longitudinal characterization of sleep/wake and electroencephalographic activity in the R6/2 mouse model of Huntington’s disease to determine whether analogous electroencephalographic ‘signatures’ could be identified early in disease…