Biomedical sciences publications
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Prolyl Endopeptidase Activity in Bronchoalveolar Lavage Fluid: A Novel Diagnostic Biomarker in a Guinea Pig Model of Invasive Pulmonary Aspergillosis
We are investigating secreted fungal proteases as novel biomarkers for the diagnosis of invasive pulmonary aspergillosis.
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Blocking the B7-H4 Pathway with Novel Recombinant Antibodies Enhances T Cell-Mediated Antitumor Responses
We have recently demonstrated that the expression of B7-H4 on the surface of malignant cells in vivo is inducible, and that novel anti-B7-H4 recombinant antibodies can reverse the inhibition of…
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In Situ Spectrophotometric Measurement of Dissolved Inorganic Carbon in Seawater
SEAS-DIC is a new in situ instrument designed to provide calibrated, high-frequency, long-term measurements of DIC in marine and fresh waters. This instrument, the first spectrophotometric system capable of automated…
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Alpha4beta2 Nicotinic Receptors Play a Role in the nAChR-Mediated Decline in l-Dopa-Induced Dyskinesias in Parkinsonian Rats
The present experiments were done to determine if alpha4beta2* nAChRs are also involved in l-dopa-induced dyskinesias. Since alpha4alpha5beta2 nAChRs are also predominantly on striatal dopamine terminals, these data suggest that…
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Dose-Dependent Efficacy and Safety Toxicology of Hydroxypyridinonate Actinide Decorporation Agents in Rodents: Towards a Safe and Effective Human Dosing Regimen
The results of these studies add to the growing body of evidence that both decorporation agents have remarkable decorporation efficacy properties and promising safety toxicology profiles.
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Estradiol Modulates Recovery of Rem Sleep in a Time-of-Day-Dependent Manner
In this study, we asked whether the effect of ovarian hormones on sleep is mediated via circadian or homeostatic regulatory mechanisms.
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Fiber Tract-Driven Topographical Mapping (FTTM) Reveals Microstructural Relevance for Interhemispheric Visuomotor Function in the Aging Brain
We present a novel approach – DTI-based fiber tract-driven topographical mapping – to map and measure the influence of age on the integrity of interhemispheric fibers and challenge their selective…
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Animal Care Practices in Experiments on Biological Rhythms and Sleep: Report of the Joint Task Force of the Society for Research on Biological Rhythms and the Sleep Research Society
This report reviews requirements for experiments on biological rhythms and sleep and discusses how scientific considerations can be reconciled with the recommendations of the Guide.
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Carbon-14 Labeling of K777
The antitrypanosomal agent K777•HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease.
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First Measurement of the BO B2Σ+ Radiative Lifetime by Laser-Induced Fluorescence Via the B2Σ+–X2Σ+ Transition
Observation of the temporal evolution of the fluorescence following laser excitation of boron monoxide molecules to the B 2Σ+ state is used to extract the radiative lifetime and collisional removal rate constant with…
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Longitudinal Analysis of the Electroencephalogram and Sleep Phenotype in the R6/2 Mouse Model of Huntington’s Disease
We conducted a longitudinal characterization of sleep/wake and electroencephalographic activity in the R6/2 mouse model of Huntington’s disease to determine whether analogous electroencephalographic ‘signatures’ could be identified early in disease…
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Curcumin Regulates Colon Cancer by Inhibiting P-Glycoprotein in Cancerous Colon Perfusion Rat Model
In the present study curcumin inhibitory action on p-glycoprotein increased permeability of irinotecan, so in the colon cancer it would be beneficial if curcumin used as add on therapy.