Biomedical sciences publications
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Comparison of a New Cobinamide-Based Method to a Standard Laboratory Method for Measuring Cyanide in Human Blood
The authors developed and validated a method to quantify cyanide based on the high binding affinity of the vitamin B12 analog, cobinamide, for cyanide and a major spectral change observed…
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The Association between Postload Plasma Glucose Levels and 38-Year Mortality Risk of Coronary Heart Disease: The Prospective NHLBI Twin Study
We aimed to evaluate whether the association between postload plasma glucose levels (ppGlucose) and long-term risk of mortality from coronary heart disease was independent of or attributable to genes and…
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Potential Reporting Bias in fMRI Studies of the Brain
Functional magnetic resonance imaging (fMRI) studies have reported multiple activation foci associated with a variety of conditions, stimuli or tasks.
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Differential Improvement in Neurocognition with Greater Antiretroviral Cns Penetration Effectiveness in Alcoholism-HIV Infection Comorbidity
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Parathyroid Hormone (PTH) and PTH-Related Peptide Domains Contributing to Activation of Different PTH Receptor-Mediated Signaling Pathways
In the present investigation, a collection of PTH(1-34) and PTHrP(1-34) peptide analogs were evaluated in orthogonal human PTH1R (hPTH1R) functional assays capturing Gs- and Gq-signaling, β-arrestin recruitment, ERK1/2 phosphorylation, and receptor…
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Acute Ethanol Reduces Reversal Cost in Discrimination Learning by Reducing Perseverance in Adolescent Rhesus Macaques
The cognitive impact of acute alcohol exposure includes deficits in discrimination and reversal learning, but traditional experimental approaches make it difficult to distinguish the effect of alcohol on discrimination learning…
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Cardiac Autonomic Activity During Sleep in Recently Sober Alcoholics
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Longitudinal Changes in Sleep EEG and Brain Structure in Adolescence
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Wernicke-Korsakoff Syndrome: A Nutritional Alcohol-Related Brain Disorder
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Antileishmanial Activity of Natural Product-Like Naphthoquinones
The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from Bignoniaceae is presented.
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Structure and Function of Parkin E3 Ubiquitin Ligase Reveals Aspects of RING and HECT Ligases
Here we present the 1.58 Å structure of Parkin-R0RBR, revealing the fold architecture for the four RING domains, and several unpredicted interfaces.
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Interleukin-6 Gene Polymorphism (−174 G/C) is Associated with Toxoplasmic Retinochoroiditis
This study suggests that the genotypes related with a lower production of IL-6 may be associated with the occurrence of TR.