Biomedical sciences publications
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Implicit Alcohol-Related Associations Affect Decision-Making in Abstinent Alcoholics
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Intrinsic Functional Connectivity in Alcoholism: Test-Retest Stability and Normalization with Sobriety
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Importance of the Nicotinic Acetylcholine Receptor System in the Prefrontal Cortex
In this work we review, in light of the latest findings, how nicotinic agonists may be acting in the PFC to influence cognitive function.
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In Vivo Measurement of Aldehyde Dehydrogenase-2 Activity in Rat Liver Ethanol Model Using Dynamic MRSI of Hyperpolarized [1-(13) C] Pyruvate
In this work, we show that dynamic MRSI of hyperpolarized pyruvate and its conversion to [1-13C]lactate can provide an indirect in vivo measurement of ALDH2 activity via the concentration of NADH.
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Polysomnographic Validation of a Wireless Dry Headband Technology for Sleep Monitoring in Healthy Young Adults
The present study aimed to explore the validity and reliability of a wireless dry headband technology for sleep monitoring (WS), through a comparison with concurrent polysomnographic (PSG) recording in healthy…
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Investigating Hydrophobic Ligand-Receptor Interactions in Parathyroid Hormone Receptor Using Peptide Probes
On the basis of a peptide reported in the literature, referred to here as the Parent Peptide, we conducted systematic SAR analyses to investigate the effects of altering peptide hydrophobicity…
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Designing Bifunctional Nop Receptor-Mu Opioid Receptor Ligands from Nop Receptor-Selective Scaffolds. Part I
We report here our forays into the structure–activity relationships for discovering ‘bifunctional’ NOP–mu opioid receptor (MOP) ligands, starting from our NOP-selective scaffolds.
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Non-Clinical Safety Evaluation of Xoma 3AB, a Novel Triple Antibody Drug Product Targeting Botulinum Toxin Type a, in Sprague-Dawley Rats
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Beta-Carotene Biosynthesis in Probiotic Bacteria
To increase vitamin A coverage in malnourished children, we propose to engineer a probiotic bacterium that will produce β-carotene in the intestine, which will be metabolized to vitamin A.
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Relationship between Cardiovascular Resting State and Visual Attention
We investigated the relationship between blood pressure, resting heart rate and heart rate variability (HRV) and performance in a visuospatial attention task comparing normotensive and hypotensive young adults.
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Evoked Responses During Sleep in Young Heavy Drinkers
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Decision-Making and Brain Structural Substrates in Alcoholism, Hiv Infection, and Their Comorbidity