Biomedical sciences publications
-
A New Perspective for Schizophrenia: TAAR1 Agonists Reveal Antipsychotic- and Antidepressant-Like Activity, Improve Cognition and Control Body Weight
We show that activation of the trace amine-associated receptor 1 (TAAR1), a modulator of monoaminergic neurotransmission, represents a novel therapeutic option.
-
Discovering the Determinants of Diversity in the Human NK Cell Repertoire by Mass Cytometry
To provide a framework for understanding how perturbations in expression of NKRs influence disease pathogenesis, we defined the phenotypic heterogeneity of NK cells in 22 healthy individuals (ages 21-62; M=10,…
-
Evidence of Oxidative Stress in Young and Aged DJ-1-Deficient Mice
Here, we investigate the impact of aging and DJ-1 deficiency in transgenic mice.
-
Network Analysis of the Whole Saliva Transcriptome, Psychosocial Stressor Exposure and Tobacco Use
-
Activation of Heme Biosynthesis by a Small Molecule That Is Toxic to Fermenting Staphylococcus Aureus
Here, we describe the identification of a small molecule activator of HssRS that induces endogenous heme biosynthesis by perturbing central metabolism.
-
Modulation of Limbic-Cerebellar Functional Connectivity Enables Alcoholics to Recognize Who Is Who
Using an fMRI paradigm, we investigated whether memory performance by alcoholics on a face–name association test previously observed to be problematic for alcoholics could be explained by desynchronous activity between…
-
A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents
The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.
-
Frequency-Selective Surface Coupled Metal-Oxide-Metal Diodes
In this work we investigate integrating MOM diodes with a slot antenna Frequency Selective Surface (FSS). This maximizes the electromagnetic capture area while minimizing the transmission line length which helps…
-
Midbrain-Driven Emotion and Reward Processing in Alcoholism
Enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. We speculate that such tuning is normally associated with behavioral conditioning to optimize responses but here contributed to…
-
Pharmacological Characterization of GPR120 Ligands
The goal of the current study was to understand GPR120 ligand selectivity by testing agonist activity of various fatty acids in cell based assays to measure G-protein activated second messengers,…
-
SR16388 Impairs Protein Homeostasis and Induces Autophagy in Diverse Human Cancer Cell Lines
SR16388 is a novel amino steroid that targets estrogen-binding proteins including genomic estrogen receptors.
-
Genetic Analysis of a Population Heavy Drinking Phenotype Identifies Risk Variants in Whites
This proof-of-concept analysis examined whether population data of lifetime heaviest alcohol consumption may be used to identify genetic loci that modulate risk.