Biomedical sciences publications
-
Discovery of a Splicing Regulator Required for Cell Cycle Progression
Here we describe a new G1 mutant from an ancient family of apicomplexan protozoans. Toxoplasma gondii temperature-sensitive mutant 12-109C6 conditionally arrests in the G1 phase due to a single point mutation in…
-
Nicotinic Acetylcholine Receptor Variation and Response to Smoking Cessation Therapies
Objective: To evaluate the association of nAChR single nucleotide polymorphism with abstinence in trials of smoking cessation therapies.
-
Alpha7 Neuronal Nicotinic Receptors as a Drug Target in Schizophrenia
Preclinical and clinical data suggest that neuronal α7nAChRs play an important role in cognitive functions. Moreover, some, but not all, early clinical trials conducted with α7nAChR agonists show cognitive benefits…
-
Characterization of a Diffusible Signaling Factor from Xylella Fastidiosa
We describe here the isolation and characterization of an X. fastidiosa DSF (XfDSF) as 2(Z)-tetradecenoic acid. This compound was isolated both from recombinant Erwinia herbicola expressing X. fastidiosa rpfF and…
-
The Tissint Martian Meteorite as Evidence for the Largest Impact Excavation
Here we show that the Tissint meteorite, a 2011 meteorite fall, contains virtually all the high-pressure phases (seven minerals and two mineral glasses) that have been reported in isolated occurrences…
-
A Mechanism of Rapidly Reversible Cerebral Ventricular Enlargement Independent of Tissue Atrophy
Here, multimodal imaging, incorporating structural MRI, MRS, and DWI, was used in rats exposed to binge ethanol to provide insight into a mechanism of reversible ventricular enlargement.
-
Understanding the Sleep-Wake Cycle: Sleep, Insomnia, and the Orexin System
Andrew D. Krystal, MD, MS, gathered a panel of experts in the area of the sleep-wake cycle and insomnia to review recent research and advances in understanding, current treatments for…
-
Remapping the Brain to Compensate for Impairment in Recovering Alcoholics
We tested whether previously published functional magnetic resonance imaging data acquired in 15 recovering alcoholics and 15 controls at rest and while performing a spatial working memory task would fulfill…
-
Modulation of the Cannabinoid Receptors by Hemopressin Peptides
The exciting finding of endocannabinoid system modulation by the nonapeptide hemopressin and its N-terminal extensions has highlighted the complexity of cannabinoid biology and pharmacology and sparked interest for therapeutic purposes.
-
A Multi-Omic Systems Approach to Elucidating Yersinia Virulence Mechanisms
In this study, a temporal multi-omic analysis of YP and YPT at physiologically relevant temperatures was performed to gain insights into how an acute and highly lethal bacterial pathogen, YP,…
-
Lessons from an Online Stop-Smoking Intervention: Adaptations for Mobile Implementation
A web-based tailored intervention yields valuable lessons for transitioning content from personal computers to the smaller form factor of a mobile device.
-
A Systematic Quantitative Proteomic Examination of Multidrug Resistance in Acinetobacter Baumannii
We have compared the proteome of the multidrug resistant strain BAA-1605, with the proteome of the drug-sensitive strain ATCC 17978, using iTRAQ labeling and online 2D LC/MS/MS for peptide/protein identification.