Biomedical sciences publications
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Alpha7 Neuronal Nicotinic Receptors as a Drug Target in Schizophrenia
Preclinical and clinical data suggest that neuronal α7nAChRs play an important role in cognitive functions. Moreover, some, but not all, early clinical trials conducted with α7nAChR agonists show cognitive benefits…
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Immunoregulatory Profile of Monocytes from Cutaneous Leishmaniasis Patients and Association with Lesion Size
We evaluated peripheral blood CD14+ monocytes for the expression of immunoregulatory cytokines, co-stimulatory molecules and TLR9 from cutaneous leishmaniasis patients infected with L. braziliensis and noninfected individuals.
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The Twin Research Registry at SRI International
Twins in the TRR have participated in studies of complex, clinically relevant phenotypes that would not be feasible to measure in larger samples.
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Understanding the Sleep-Wake Cycle: Sleep, Insomnia, and the Orexin System
Andrew D. Krystal, MD, MS, gathered a panel of experts in the area of the sleep-wake cycle and insomnia to review recent research and advances in understanding, current treatments for…
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Remapping the Brain to Compensate for Impairment in Recovering Alcoholics
We tested whether previously published functional magnetic resonance imaging data acquired in 15 recovering alcoholics and 15 controls at rest and while performing a spatial working memory task would fulfill…
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Modulation of the Cannabinoid Receptors by Hemopressin Peptides
The exciting finding of endocannabinoid system modulation by the nonapeptide hemopressin and its N-terminal extensions has highlighted the complexity of cannabinoid biology and pharmacology and sparked interest for therapeutic purposes.
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A Multi-Omic Systems Approach to Elucidating Yersinia Virulence Mechanisms
In this study, a temporal multi-omic analysis of YP and YPT at physiologically relevant temperatures was performed to gain insights into how an acute and highly lethal bacterial pathogen, YP,…
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Lessons from an Online Stop-Smoking Intervention: Adaptations for Mobile Implementation
A web-based tailored intervention yields valuable lessons for transitioning content from personal computers to the smaller form factor of a mobile device.
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A Systematic Quantitative Proteomic Examination of Multidrug Resistance in Acinetobacter Baumannii
We have compared the proteome of the multidrug resistant strain BAA-1605, with the proteome of the drug-sensitive strain ATCC 17978, using iTRAQ labeling and online 2D LC/MS/MS for peptide/protein identification.
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Variation in Longitudinal Trajectories of Regional Brain Volumes of Healthy Men and Women (Ages 10 to 85 Years) Measured with Atlas-Based Parcellation of MRI
We calculated trajectories of regional brain volume changes from T1-weighted (SPGR) MRI data, quantified with our automated, unsupervised SRI24 atlas-based registration and parcellation method.
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Sub-Anesthetic Concentrations of (R,S)-Ketamine Metabolites Inhibit Acetylcholine-Evoked Currents in Alpha 7 Nicotinic Acetylcholine Receptors
The effect of the (R,S)-ketamine metabolites (R,S)-norketamine, (R,S)-dehydronorketamine, (2S,6S)-hydroxynorketamine and (2R,6R)-hydroxynorketamine on the activity of α7 and α3β4 neuronal nicotinic acetylcholine receptors was investigated using patch-clamp techniques.
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Retrodialysis of N/Ofq into the Nucleus Accumbens Shell Blocks Cocaine-Induced Increases in Extracellular Dopamine and Locomotor Activity
This study sought to examine the effects of retrodialyzed N/OFQ on the cocaine-induced increase in extracellular dopamine levels in the NAc, as well as locomotor activity, in freely moving rats.