Biomedical sciences publications
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Computing Minimal Nutrient Sets from Metabolic Networks Via Linear Constraint Solving
We present a method for computationally determining alternative growth media for an organism based on its metabolic network and transporter complement.
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TB Mobile: A Mobile App for Anti-Tuberculosis Molecules with Known Targets
In order to learn from prior work we have collated information on molecules screened versus Mtb and their targets which has been made available in the Collaborative Drug Discovery (CDD) database.
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β-Carotene Biosynthesis in Probiotic Bacteria
To increase vitamin A coverage in malnourished children, we propose to engineer a probiotic bacterium that will produce β-carotene in the intestine, which will be metabolized to vitamin A.
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Proteolytic Enzymes as Biomarkers of Focal Segmental Glomerulosclerosis
Here, the library was utilized to map the global proteolytic specificities of plasma samples obtained from patients with the nephrotic syndrome, known as focal segmental glomerulosclerosis (FSGS).
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Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer
This study bridges a carbohydrate microarray discovery and a large-scale serological validation of anti-oligomannose antibodies as novel serum biomarkers of aggressive prostate cancer.
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The Nicotine-Mediated Decline in L-Dopa-Induced Dyskinesias Is Associated with a Decrease in Striatal Dopamine Release
This study investigates whether nicotine may exert its beneficial effects by modulating pre-synaptic dopaminergic function.
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Comorbidity of Alcoholism, HIVInfection and Hepatitis C: In Vivo Brain Imaging
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Are Women Who Smoke at Higher Risk for Lung Cancer Than Men Who Smoke?
We tested sex-smoking interaction in association with lung cancer risk within a population-based case-control study, the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study (Lombardy, Italy, 2002–2005).
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Evaluation of IL17A Expression and of IL17A, IL17F and IL23R Gene Polymorphisms in Brazilian Individuals with Periodontitis
The aim of present study was to evaluate the expression of IL17A and occurrence of the IL17A (rs2275913), IL17F (rs763780) and IL23R (rs11209026) gene polymorphisms in different clinical forms or…
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Circadian Rhythm Disorders: Does Sex Matter?
There are sex-related differences in circadian rhythms with women having shorter intrinsic periods and earlier phase of both temperature and melatonin rhythms relative to men.
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Sex Differences in Sleep
There are sex differences in sleep behavior with women reporting more sleep problems and a poorer sleep quality than men across a wide age range.
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Discovery of a Splicing Regulator Required for Cell Cycle Progression
Here we describe a new G1 mutant from an ancient family of apicomplexan protozoans. Toxoplasma gondii temperature-sensitive mutant 12-109C6 conditionally arrests in the G1 phase due to a single point mutation in…