Biomedical sciences publications
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Two SHIPs Passing in the Middle of the Immune System
Using conditional knockouts of SHIP1 in either the myeloid or T-cell-lineage of mice, the authors show that the regulated development of Treg cells is controlled directly by cell-intrinsic SHIP1, and…
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Cannabinoid Receptor Activation Correlates with the Proapoptotic Action of the beta(2)-Adrenergic Agonist (R,R ‘)-4-Methoxy-1-Naphthylfenoterol in HepG2 Hepatocarcinoma Cells
We compare the effect of the β2-AR agonists (R,R′)-fenoterol (Fen) and (R,R′)-4-methoxy-1-naphthylfenoterol (MNF) on signaling and cell proliferation in HepG2 hepatocarcinoma cells by using Western blotting and [3H]thymidine incorporation assays.
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Pain Sensitivity and Opioid Analgesia: a Pharmacogenomic Twin Study
This study used a twin paradigm to provide a global estimate of the genetic and environmental contributions to inter-individual differences in pain sensitivity and analgesic opioid effects.
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Long-Term Behavioral, Electrophysiological, and Neurochemical Monitoring of the Safety of an Experimental Antiepileptic Implant, the Muscimol-Delivering Subdural Pharmacotherapy Device in Monkeys Laboratory Investigation
The authors evaluated the extent to which the Subdural Pharmacotherapy Device (SPD), chronically implanted over the frontal cortex to perform periodic, localized muscimol-delivery/CSF removal cycles, affects overall behavior, motor performance,…
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Highly Conserved CDR3 Region in Circulating CD4(+)V Beta 5(+) T Cells may be Associated with Cytotoxic Activity in Chagas Disease
The aim of this work was to determine whether T cells expressing this particular Vβ region displayed variable or restricted CDR3 sequences, as an indicator of the nature of the…
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Genotoxicity of the Cancer Chemopreventive Drug Candidates CP-31398, SHetA2, and Phospho-Ibuprofen
The genotoxic activities of three cancer chemopreventive drug candidates, CP-31398 (a cell permeable styrylquinazoline p53 modulator), SHetA2 (a flexible heteroarotinoid), and phospho-ibuprofen (PI, a derivative of ibuprofen) were tested.
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Quantification of Glutamate and Glutamine Using Constant-Time Point-Resolved Spectroscopy at 3 T
To quantify Glu and Gln, a time-domain basis set was constructed taking into account metabolite T 2 relaxation times and dephasing from B 0 inhomogeneity.
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Discovery and Optimization of Benzotriazine Di-N-Oxides Targeting Replicating and Nonreplicating Mycobacterium Tuberculosis
These data along with measurements of the physiochemical properties and pharmacokinetic profile demonstrate that BTOs have the potential to be developed into a new class of antitubercular drugs.
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Anterograde Episodic Memory in Korsakoff Syndrome
In this review we highlight the historical studies that examined anterograde episodic memory processes in KS, present a timeline and evidence supporting the myriad theories proffered to account for this…
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The Stereoselective Sulfate Conjugation of 4′-Methoxyfenoterol Stereoisomers by Sulfotransferase Enzymes
The presystemic sulfate conjugation of the stereoisomers of 4′-methoxyfenoterol, (R,R′)-MF, (S,S′)-MF, (R,S′)-MF, and (S,R′)-MF, was investigated using commercially available human intestinal S9 fractions, a mixture of sulfotransferase (SULT) enzymes.
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Alphaviruses: Population Genetics and Determinants of Emergence
This review discusses the ecology, epidemiology and molecular virology of the alphaviruses, then focuses on three of the most important members of the genus.
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Cortical nNOS Neurons Co-Express the NK1 Receptor and are Depolarized by Substance P in Multiple Mammalian Species
To evaluate the degree of co-expression of nNOS and NK1 in the cortex among mammals, we used double immunofluorescence for nNOS and NK1 and determined the anatomical distribution in mouse,…