Biomedical sciences publications
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Quantification of in Vivo Metabolic Kinetics of Hyperpolarized Pyruvate in Rat Kidneys Using Dynamic 13C MRSI
We developed an efficient quantification framework employing a spiral-based dynamic spectroscopic imaging approach.
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Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
We used a targeted GC-MS metabolomics platform to measure a panel of metabolites that may predict variation in statin LDL-C lowering efficacy.
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Mannich Reaction Derivatives of Novobiocin with Modulated Physiochemical Properties and Their Antibacterial Activities
Synthetic derivatives of the natural product antibiotic novobiocin were synthesized in order to improve their physiochemical properties.
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An Enhanced β Turn in Water
A series of tetrapeptides based on the sequence Ac-Ala-Pro-Ala-Ala-NH2 containing all possible combinations of l- and d-amino acids was synthesized.
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Anatomic Closure of the Premature Patent Ductus Arteriosus: the Role of CD14+/CD163+ Mononuclear Cells and VEGF in Neointimal Mound Formation
We hypothesized that VEGF plays a crucial role in attracting CD14/CD163 mononuclear cells to the ductus lumen and that CD14/CD163 cell adhesion to the ductus lumen is important for neointimal…
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Comparison of Binding and Functional Activity Profiles for a Set of Nicotinic Acetylcholine Receptor Ligands Across Multiple Alpha 6*Expression Systems
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Targeting the Nicotinic Alpha7 Acetylcholine Receptor to Enhance Cognition in Disease
The current review focuses on the neurobiology of the α7nAChR, its role in cognition and the development status of some of the most promising molecules advancing for the treatment of…
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A Gene Expression Signature from Peripheral Whole Blood for Stage I Lung Adenocarcinoma
We measured gene expression from lung tissue and peripheral whole blood from adenocarcinoma cases and controls to identify dysregulated lung cancer genes that could be tested in blood to improve…
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Biodistribution, Toxicology, and Radiation Dosimetry of 5-HT1A-Receptor Agonist Positron Emission Tomography Ligand [11C]CUMI-101
The Medical Internal Radiation Dose estimates indicate the maximum permissible single-study dosage of CUMI-101 in humans is 52 mCi with testes and urinary bladder as the critical organ for males…
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CD4(+) T Cells Defined By Their V Beta T Cell Receptor Expression Are Associated with Immunoregulatory Profiles and Lesion Size in Human Leishmaniasis
In order to measure the host T cell response to Leishmania infection, we have measured the expansion, activation state and functional potential of specific T cells as identified by their T cell…
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Analytical Methods for the Bioavailability Evaluation of Hydroxypryridinonate Actinide Decorporation Agents in Pre-clinical Pharmacokinetic Studies
The described bioanalytical detection methods were successfully applied to the selection of solid-state forms of 5-LIO and 3,4,3-LI for future preclinical development activities, and will be adapted for use with…
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Neglected Diseases: In Need of Bare Necessities and Breakthroughs