Biomedical sciences publications
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Gene-Centric Analysis of Serum Cotinine Levels in African and European American Populations
We conducted a genetic association study of the biomarker in African American and European American subjects from the Coronary Artery Risk Development in Young Adults study using a chip containing…
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The ST Pinch: A Side Chain-to-Side Chain Hydrogen-Bonded Motif
The ST Pinch is a 12-membered hydrogen-bonded motif (Ser/Thr-Xaa-Ser/Thr) involving the side chain oxygen atoms of two Ser/Thr residues. We identified the ST Pinch in 104 proteins in a database…
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K-Complexes Are Not Preferentially Evoked to Combat Sounds in Combat-Exposed Vietnam Veterans With and Without Post-Traumatic Stress Disorder
The primary objective was to compare the evoked K-complex response to salient versus non-salient auditory stimuli in combat-exposed Vietnam veterans with and without post-traumatic stress disorder (PTSD).
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MRI Estimates of Brain Iron Concentration in Normal Aging Using Quantitative Susceptibility Mapping
We use recently-developed Quantitative Susceptibility Mapping (QSM) methodology to estimate the tissue magnetic susceptibility based on MRI signal phase.
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Partial Recovery of Alcohol Dependence-Related Deficits in Sleep Evoked Potentials Following 12 Months of Abstinence
The present study tested the hypothesis that the amplitude of K-complex related evoked potential components would increase with prolonged abstinence from alcohol.
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Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS.
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Developmental Changes in the Sleep Electroencephalogram of Adolescent Boys and Girls
The present study seeks to resolve some of these issues in a combined cross-sectional and longitudinal analysis of sleep EEG in adolescents.
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Peptides Derived from the Prohormone proNPQ/Spexin are Potent Central Modulators of Cardiovascular and Renal Function and Nociception
Here we demonstrate biological activity for two peptides present within proNPQ/spexin. NPQ/spexin and NPQ 53–70 have differing renal and cardiovascular effects when administered intracerebroventricularly or intravenously into rats.
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Moving “Forward” in Plasmodium Genetics Through a Transposon-Based Approach
The introduction of forward genetics has provided novel means to gain a better understanding of gene functions and their associated phenotypes in Plasmodium.
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Hemopressin Forms Self-Assembled Fibrillar Nanostructures Under Physiologically Relevant Conditions
On the basis of hemopressin’s potential in therapeutic applications and the lack of a structure–activity relationship study in literature, we aimed to determine the conformational features of hemopressin under physiological…
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Carbohydrate Antigen Microarrays
This chapter describes one of my laboratory’s working protocols for carbohydrate-based microarrays.
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Combinatorial Glycoarray
We have developed a semi-automated system for assaying lectin binding to large numbers of glycolipid complexes simultaneously.