Biomedical sciences publications
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Absence of Association Between Specific Common Variants of the Obesity-Related Fto Gene and Psychological and Behavioral Eating Disorder Phenotypes
To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms of the FTO gene were genotyped in individuals with anorexia nervosa (AN) and 677…
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The Combination of Cobinamide and Sulfanegen Is Highly Effective in Mouse Models of Cyanide Poisoning
We are developing two new cyanide antidotes—cobinamide, a vitamin B12 analog, and sulfanegen, a 3-mercaptopyruvate prodrug. Both drugs can be given by intramuscular administration, and therefore could be used to…
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Effects of Acute Alcohol on Sleep Evoked Potentials in Heavy Drinking and Light Drinking Male College Students
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Personality Disorders in Women with Severe Premenstrual Syndrome
The comorbidity of a personality disorder and severe PMS places an additive burden on general life functioning and may have implications for psychiatric treatment or medication given to those with…
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Synthesis of 3H-Labeled Tetrabenazine (TBZ)
Our method provides tritium-labeled TBZ with high specific activity and radiochemical purity, which allow the further investigation of a TBZ in the neurological field.
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Multiple Gap-Filling of Flux-Balance Models
Keywords: Artificial Intelligence, Artificial Intelligence Center, AIC
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Dynamic and High-Resolution Metabolic Imaging of Hyperpolarized [1- 13C]-Pyruvate in the Rat Brain Using a High-Performance Gradient Insert
Here a high-performance gradient insert was used in combination with undersampled spiral CSI to increase either the imaging speed or the spatial resolution of hyperpolarized 13C metabolic imaging on a clinical…
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The Human Epithelial Carcinoma Antigen Recognized By Monoclonal Antibody Ae3 Is Expressed on a Sulfoglycolipid in Addition to Neoplastic Mucins
We have carried out carbohydrate microarray analyses of one of the monoclonal antibodies, AE3, that has been regarded the ‘most carcinoma specific’ in respect to its ability to detect HCA…
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Detection of Inflammatory Arthritis By Using Hyperpolarized 13 C-Pyruvate with Mr Imaging and Spectroscopy
The data presented herein suggest that the presence of inflammation may be detected at 13C-MR spectroscopy as the increased conversion of hyperpolarized 13C-pyruvate into 13C-lactate.
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Genetic Variability of Smoking Persistence in African Americans
We undertook an association analysis by using a genotyping array that includes 2,100 genes to analyze smoking persistence in unrelated African American participants from the Atherosclerosis Risk in Communities study.
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Effect of Fenoterol Stereochemistry on the β2 Adrenergic Receptor System: Ligand-Directed Chiral Recognition
The β2 adrenergic receptor (β2-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a β2-AR selective agonist that has two centers of…
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Nicotinic Receptor Agonists Decrease L-Dopa-Induced Dyskinesias Most Effectively in Partially Lesioned Parkinsonian Rats
To further understand how nicotine mediates its antidyskinetic action, we investigated the effect of nicotinic receptor (nAChR) agonists in unilateral 6-OHDA-lesioned rats with varying striatal damage.