Biomedical sciences publications
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Analytical Methods for the Bioavailability Evaluation of Hydroxypryridinonate Actinide Decorporation Agents in Pre-clinical Pharmacokinetic Studies
The described bioanalytical detection methods were successfully applied to the selection of solid-state forms of 5-LIO and 3,4,3-LI for future preclinical development activities, and will be adapted for use with…
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Clinical Aspects of Chagas Disease and Implications for Novel Therapies
The interaction between the protozoan parasite Trypanosoma cruzi and the human host dates back 9,000 years, as demonstrated by molecular analysis of material obtained from Andean mummies indicating the presence of the…
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The AMPK Stress Response Pathway Mediates Anoikis Resistance Through Inhibition of mTOR and Suppression of Protein Synthesis
Here we show that, after detachment, mouse embryonic fibroblasts transformed by K-Ras or ETV6-NTRK3 activate a transcriptional response overrepresented by genes related to bioenergetic stress and the AMP-activated protein kinase…
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Immunoregulatory and Effector Activities in Human Cutaneous and Mucosal Leishmaniasis: Understanding Mechanisms of Pathology
By studying the immune response from CL and ML patients in both the peripheral blood and in situ, we have learned much concerning the dynamics of the host–pathogen interaction that…
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Ethanol-Induced Changes in the Expression of Proteins Related to Neurotransmission and Metabolism in Different Regions of the Rat Brain
Despite extensive description of the damaging effects of chronic alcohol exposure on brain structure, mechanistic explanations for the observed changes are just emerging.
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Multi-Modality Imaging Assessment of Alcoholism’s Damaging Effect on Brain Systems and Circuitry
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Providing Coaching and Cotinine Results to Preteens to Reduce Their Secondhand Smoke Exposure: a Randomized Trial
This trial determined whether coaching and cotinine feedback provided to preteens can reduce their SHSe.
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A Fluoroquinolone-Resistant Acinetobacter Baumannii Without the Quinolone Resistance-Determining Region Mutations
To address the progression of antibiotic resistance in A. baumannii ATCC 17978, we attempted to isolate A. baumannii ATCC 17978 ciprofloxacin-resistant mutants...
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Robust Substrate Profiling Method Reveals Striking Differences in Specificities of Serum and Lung Fluid Proteases
We hypothesized that a combinatorial protease substrate library could be used effectively to identify similarities and differences between serum and bronchoalveolar lavage fluid (BALF), two body fluids that are clinically…
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Nonprofit Pharma: Solutions to What Ails the Industry
To provide a perspective on NPO business models, a number of SRI case studies spanning a broad range of technical and business initiatives will be summarized.
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Structural Determinants of Opioid and NOP Receptor Activity in Derivatives of Buprenorphine
In order to investigate the role of NOP activation further, a series of buprenorphine analogues has been synthesized with the aim of increasing affinity for the NOP receptor.
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Drug Targets for Cognitive Enhancement in Neuropsychiatric Disorders
The investigation of novel drug targets for treating cognitive impairments associated with neurological and psychiatric disorders remains a primary focus of study in central nervous system (CNS) research.