Biomedical sciences publications
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Patent Ductus Arteriosus Ligation Alters Pulmonary Gene Expression in Preterm Baboons
Ibuprofen-induced ductus closure improves pulmonary mechanics and increases alveolar surface area in premature baboons compared with baboons with a persistent patent ductus arteriosus (PDA).
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Pharmacogenetics of Smoking Cessation in General Practice: Results from the Patch Ii and Patch in Practice Trials
The results and lessons learned from this general practice-based pharmacogenetic research programme provide transportable insights at the transition to the second generation of pharmacogenetic and genomic investigations of smoking cessation…
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The Virulence of the Opportunistic Fungal Pathogen Aspergillus Fumigatus Requires Cooperation Between the Endoplasmic Reticulum-Associated Degradation Pathway (Erad) and the Unfolded Protein Response (Upr)
We examined the contribution of these integrated pathways to the growth and virulence of A. fumigatus, focusing on the ERAD protein DerA and the master regulator of the UPR, HacA.
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Glutathione Peroxidase 4 Is Associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson’s Brain
This study demonstrates an up-regulation of GPX4 in neurons of substantia nigra and association of this protein with dystrophic axons in striatum of Parkinson's brain, indicating a possible neuroprotective role.
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Alcohol Exposure and Nutritional Deficiency in Rat Models: Translational Neuroimaging Studies
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Effects of Rg3487 at the Alpha 7 Beta 2 Nicotinic Acetylcholine Receptor Expressed in Xenopus Oocytes
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Cerebral Blood Flow in Posterior Cortical Nodes of the Default Mode Network Decreases with Task Engagement But Remains Higher Than in Most Brain Regions
We employed 3D arterial spin labeling imaging to examine regional cerebral blood flow (CBF) during rest, a spatial working memory task, and a second rest.
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Inotropic Contractile Reserve and Response to Cardiac Resynchronization Therapy in Patients with Markedly Remodeled Left Ventricle
The aim of this study was to evaluate the role of ICR in predicting response to CRT in patients with markedly remodeled left ventricles.
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Alpha 6 Beta 2*and Alpha 4 Beta 2*Nicotinic Acetylcholine Receptors as Drug Targets for Parkinson’s Disease
Here we review nAChRs with particular emphasis on the subtypes that contribute to basal ganglia function. Accumulating evidence suggests that drugs targeting α6β2* and α4β2* nAChR may prove useful in…
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From Biology to Inspiration and Back: Is the Pallidal Complex a Reservoir?
This paper explores parallels between Reservoir Computing models and basal ganglia nuclei including the subthalamic nucleus and globus pallidus.
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In Situ Determination of Total Dissolved Inorganic Carbon By Underwater Membrane Introduction Mass Spectrometry
Factors affecting the response of the membrane introduction mass spectrometer (MIMS) system were examined to optimize calibrations and enhance the accuracy of component ocean carbon system measurements.
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Sheet-Like White Matter Fiber Tracts: Representation, Clustering, and Quantitative Analysis
We introduce an automated and probabilistic method for subject-specific segmentation of sheet-like fiber tracts.