Biomedical sciences publications
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Independent Contributions of Cortical Gray Matter, Aging, Sex and Alcoholism to K-Complex Amplitude Evoked During Sleep
The amplitude of the N550 component derived from the averaged evoked K-complex decreases with normal aging and with alcoholism. The study was designed to determine whether these declines are related…
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Recommendations for the Validation of Flow Cytometric Testing During Drug Development: I Instrumentation
This paper presents a consensus methodological approach that the authors have used successfully to ensure data integrity in flow cytometric studies conducted during drug development.
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Computational Databases, Pathway and Cheminformatics Tools for Tuberculosis Drug Discovery
Cheminformatic techniques have been leveraged and are examined in this review. We suggest that these computational approaches should be optimally integrated within a workflow with experimental approaches to accelerate TB…
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In Vivo MRSI of Hyperpolarized [1-13C]Pyruvate Metabolism in Rat Hepatocellular Carcinoma
We implemented a three-dimensional MRSI sequence to investigate this potential hallmark of cellular metabolism in rat livers bearing HCC (n = 7 buffalo rats).
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Diamino-1,2,4-Triazole Derivatives Are Selective Inhibitors of Tyk2 and Jak1 Over Jak2 and Jak3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.
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Neurocircuitry of Emotion and Cognition in Alcoholism: Contributions from White Matter Fiber Tractography
An understanding of the role of cortico-limbic fiber degradation in emotional dysregulation in alcoholism is now emerging.
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Captopril Increases the Intensity of Monocyte Infection By Trypanosoma Cruzi and Induces Human T Helper Type 17 Cells
Here we showed that captopril increases the intensity of T. cruzi infection of human monocytes in vitro. The increased parasitism was accompanied by up-regulated expression of ACE in human monocytes.
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Fiber Tracking Functionally Distinct Components of the Internal Capsule
To examine the microstructural condition of this fiber system and to test functional correlates of its sectors in health and aging, adults were examined with diffusion tensor imaging fiber tracking…
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A. Diamino-1,2,4-Triazole Derivatives are Selective Inhibitors of TYK2 and JAK1 Over JAK2 and JAK3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.
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Diffusion Tensor Imaging in Aging and Age-Related Neurodegenerative Disorders
This chapter reviews evidence for changes in normal aging as the context for establishing abnormalities marking neurological and psychiatric conditions...
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The Rational Design of a Novel Potent Analogue of the 5′-AMP-Activated Protein Kinase Inhibitor Compound C with Improved Selectivity and Cellular Activity
We have designed and synthesized analogues of compound C, a non-specific inhibitor of 5′-AMP-activated protein kinase (AMPK), using a computational fragment-based drug design (FBDD) approach.
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EMX2 Is Epigenetically Silenced and Suppresses Growth in Human Lung Cancer
In this study, we found that EMX2 was dramatically downregulated in lung cancer tissue samples and this downregulation was associated with methylation of the EMX2 promoter.