Biomedical sciences publications
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Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature
Various methoxy- and hydroxy-substituted dibenz[c,e]oxepines were prepared via the copper(I)-induced coupling of ether-tethered arylstannanes ...
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Ubiquitin Accumulation in Autophagy-Deficient Mice Is Dependent on the Nrf2-Mediated Stress Response Pathway: a Potential Role for Protein Aggregation in Autophagic Substrate Selection
We show that tissue-specific disruption of the essential autophagy genes Atg5 and Atg7 leads to the accumulation of all detectable Ub–Ub topologies, arguing against the hypothesis that any particular Ub linkage serves as a…
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β2 Adrenergic Receptor Agonists Inhibit the Proliferation of 1321N1 Astrocytoma Cells
Experiments were conducted to determine whether the β2-AR agonist (R,R′)-fenoterol and other β2-AR agonists could attenuate mitogenesis and, if so, by what mechanism.
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Diffusion Tensor Imaging in Aging and Age-Related Neurodegenerative Disorders
This chapter reviews evidence for changes in normal aging as the context for establishing abnormalities marking neurological and psychiatric conditions...
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The Rational Design of a Novel Potent Analogue of the 5′-AMP-Activated Protein Kinase Inhibitor Compound C with Improved Selectivity and Cellular Activity
We have designed and synthesized analogues of compound C, a non-specific inhibitor of 5′-AMP-activated protein kinase (AMPK), using a computational fragment-based drug design (FBDD) approach.
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RG3487, A Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents
Cumulative evidence from these studies indicates RG3487 is a novel and potent α7nAChR partial agonist that improves cognitive performance and sensorimotor gating.
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A Parallel Chiral-Achiral Liquid Chromatographic Method for the Determination of the Stereoisomers of Ketamine and Ketamine Metabolites in the Plasma and Urine of Patients with Complex Regional Pain Syndrome
A parallel chiral/achiral LC–MS/MS assay has been developed and validated to measure the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in complex regional pain syndrome…
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Measurement of Serum, Liver, and Brain Cytokine Induction, Thiamine Levels, and Hepatopathology in Rats Exposed to a 4-Day Alcohol Binge Protocol
This study aimed to determine whether binge EtOH exposure would induce the expression of certain cytokines in blood, liver, or brain, thereby supporting the neuroinflammation hypothesis of elevated Cho.
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Signs of Preclinical Wernicke’s Encephalopathy and Thiamine Levels as Predictors of Neuropsychological Deficits in Alcoholism Without Korsakoff’s Syndrome
The purpose of this study was to determine whether meeting historical criteria for unsuspected Wernicke's encephalopathy explains why some alcoholics have severe neuropsychological deficits.
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Novel α3β4 Nicotinic Acetylcholine Receptor-Selective Ligands. Discovery, Structure-Activity Studies, and Pharmacological Evaluation
We report the discovery and SAR of a novel class of compounds that bind to the α3β4 nAChR and have no measurable affinity for the α4β2 or α7 subtype.
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Novel Alpha 3 Beta 4 Nicotinic Acetylcholine Receptor-Selective Ligands. Discovery, Structure-Activity Studies, and Pharmacological Evaluation
We report the discovery and SAR of a novel class of compounds that bind to the α3β4 nAChR and have no measurable affinity for the α4β2 or α7 subtype.
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Opioid Pharmacogenomics Using a Twin Study Paradigm: Methods and Procedures for Determining Familial Aggregation and Heritability
This ongoing study takes advantage of the twin paradigm to estimate the genetic and environmental contributions to inter-individual differences in opioid responses.