Biomedical sciences publications
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Biological Impact of Low Dose-Rate Simulated Solar Particle Event Radiation in Vivo
C57Bl6-lacZ animals were exposed to a range of low dose-rate simulated solar particle event (sSPE) radiation at the NASA-sponsored Research Laboratory (NSRL) at Brookhaven National Laboratory (BNL).
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Preclinical Pharmacokinetic, Toxicological and Biomarker Evaluation of SR16157, a Novel Dual-Acting Steroid Sulfatase Inhibitor and Selective Estrogen Receptor Modulator
SR16157 is a novel dual-acting inhibitor of estrogen action that irreversibly inhibits the estrogen biosynthetic enzyme steroid sulfatase and releases the selective estrogen receptor modulator SR16137, which blocks the estrogen…
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Improved Oral Bioavailability in Rats of SR13668, A Novel Anti-Cancer Agent
The objective of these studies was to better understand the source of low oral exposure and to develop a formulation that could be used in preclinical development studies.
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Callosal Microstructural Abnormalities in Alzheimer’s Disease and Alcoholism: Same Phenotype, Different Mechanisms
Magnetic resonance and diffusion tensor imaging data were acquired and midsagittal area, length, dorsoventral height, fractional anisotropy, and mean diffusivity of the total corpus callosum and volume of the lateral…
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Genome Sequence of the Necrotrophic Plant Pathogen Pythium Ultimum Reveals Original Pathogenicity Mechanisms and Effector Repertoire
Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species.
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Association Study of 182 Candidate Genes in Anorexia Nervosa
We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results…
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3.3: the Development of a Stationary X-Ray Source for Medical Imaging
A prototype stationary source for medical imaging is evaluated. X-ray focal spot diameters of less than 0.2 mm are formed with beam currents of up to 75 mA at beam…
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5′-AMP-Activated Protein Kinase Activity is Elevated Early During Primary Brain Tumor Development in the Rat
We used an established model of brain tumor (glioma) development in the offspring of rats exposed prenatally to the mutagen N-ethyl-N-nitrosourea.
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Molecular and Anatomical Signatures of Sleep Deprivation in the Mouse Brain
Using a systematic immediate-early gene (IEG) mapping to detect neuronal activation, the consequences of SD were mapped primarily to forebrain regions.
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Cerebral Dynamics and Metabolism of Hyperpolarized 1- 13 Cpyruvate Using Time-Resolved Mr Spectroscopic Imaging
Dynamic hyperpolarized [1-13C]pyruvate metabolic imaging in the normal anesthetized rat brain is demonstrated on a clinical 3-T magnetic resonance imaging scanner.
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Contribution of Callosal Connections to the Interhemispheric Integration of Visuomotor and Cognitive Processes
The reviewed studies on patients with callosal degradation with and without disconnection indicate a dissociation of callosal functions.
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Development and Validation of a High-Throughput Screening Assay for Human Long-Chain Fatty Acid Transport Proteins 4 and 5
The authors used mammalian cell lines stably expressing the recombinant human FATP4 and 5 and developed a high-throughput screening assay using a 96-well fluorometric imaging plate reader.