Biomedical sciences publications
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Historical Insights Into Sleep Research
The article in the present issue by Basner helps to ensure the “virtuous actions” and careful insightful science of Ernst Otto Heinrich Kohlschütter will not be forgotten.
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The Puf-Family RNA-Binding Protein Pfpuf2 Regulates Sexual Development and Sex Differentiation in the Malaria Parasite Plasmodium Falciparum
In this study we determined the function of PfPuf2, a member of the Puf family of translational repressors, in gametocytogenesis of Plasmodium falciparum.
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Metabolic Imaging in the Anesthetized Rat Brain Using Hyperpolarized [1-(13)C] Pyruvate and [1-(13)C] Ethyl Pyruvate
In this initial study, we explore the feasibility of polarizing a stable formulation of [1-13C]-EP and compare spectroscopic images of uptake and metabolism in normal anesthetized rat brain relative to…
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Dual Tasking and Working Memory in Alcoholism: Relation to Frontocerebellar Circuitry
The brain–behavior correlations suggest that alcoholics and controls relied on the integrity of certain nodes of corticocerebellar systems to perform these verbal and spatial working memory tasks, but that the…
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A Bottom-Up Biofeedback Remediation Improves Emotion Recognition in Schizophrenia: Evidence from a Visual Scan Path Pilot Study
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Monocyte Dysfunction in Sydenham’s Chorea Patients
We evaluated the activation state of monocytes, cells that are precursors of macrophages, to characterize the inflammation profile of patients.
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Mouse Urinary Biomarkers Provide Signatures of Maturation, Diet, Stress Level, and Diurnal Rhythm
We compared the volatile compositions of mouse urine using solid-phase microextraction and gas chromatography–mass spectrometry (SPME-GC/MS).
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MR Diffusion Tensor Imaging: a Window Into White Matter Integrity of the Working Brain
Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function.
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Vaccination of Rabbits with an Alkylated Toxoid Rapidly Elicits Potent Neutralizing Antibodies Against Botulinum Neurotoxin Serotype B
New Zealand White (NZW) rabbits were immunized with several different nontoxic botulinum neurotoxin serotype B (BoNT/B) preparations in an effort to optimize the production of a rapid and highly potent,…
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Advanced Vehicle Tracking in Persistent Aerial Surveillance Video
This paper presents a relational graph based approach to track thousands of vehicles from persistent wide area airborne surveillance (WAAS) videos.
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Development of a New Generation of 4-Aminoquinoline Antimalarial Compounds Using Predictive Pharmacokinetic and Toxicology Models
ADMET prediction studies were employed to evaluate a library of new molecules based on the 4-aminoquinolone-related structure of CQ.
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LC/MS Characterization of Impurities and Degradation Products of a Potent Antitumor Peptidic Dimer, CU201
An HPLC method was developed, as part of a study supported by the National Cancer Institute's (NCI's) Rapid Access to Interventional Development (RAID) program, to assess the purity and stability…