Biomedical sciences publications
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Global Reemergence of Tuberculosis: Are Host Defense Peptides an Option to Ameliorate Disease Burden?
Intermittent drug therapy due to noncompliance or poor delivery of therapy promotes the emergence of bacterial strains showing resistance to multiple drugs and the rise of extremely drug-resistant strains.
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Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs…
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Callosal Degradation in HIV-1 Infection Predicts Hierarchical Perception: a DTI Study
We tested whether HIV-related callosal white matter degradation contributes to disruption of selective lateralized visuospatial and attention processes.
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Design of Short Linear Peptides That Show Hydrogen Bonding Constraints in Water
Using a combination of an aromatic amino acid, a homoserine side chain, and a d-amino acid, a series of linear tetrapeptides were designed that adopt an “Hse turn” in water.
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Pharmacokinetics and Metabolism of (R,R)-Methoxyfenoterol in Rat
(R,R)-fenoterol (Fen), a beta(2)-adrenoceptor agonist, is under clinical investigation in the treatment of congestive heart disease.
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A Partially Linear Tree-Based Regression Model for Multivariate Outcomes
We propose a multilocus association test for the study of multivariate traits. The test is derived from a partially linear tree-based regression model for multiple outcomes.
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Increase in Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Levels and Inhibition of MMP-2 Activity in a Metastatic Breast Cancer Cell Line by an Anti-Invasive Small Molecule SR13179
We report that a novel small molecule synthetic flavanoid SR13179, which inhibits the invasion of a highly metastatic human breast cancer cell line MCF-10CA1a through Matrigel, significantly increases protein and…
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Daytime Sleepiness, Psychomotor Performance, Waking Eeg Spectra and Evoked Potentials in Women with Severe Premenstrual Syndrome
We assessed daytime sleepiness using objective and subjective measures in women with severe premenstrual syndrome (PMS) compared with women without significant premenstrual symptoms.
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Stimulation of Lateral Hypothalamic Glutamate and Acetylcholine Efflux By Nicotine: Implications for Mechanisms of Nicotine-Induced Activation of Orexin Neurons
Here, we used in vivo microdialysis to determine the effect of acute systemic or local nicotine on glutamate, acetylcholine, and GABA efflux in the LH/PFA of rats.
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Nicotinic Receptor-Mediated Reduction in L-DOPA-Induced Dyskinesias May Occur Via Desensitization
The present experiments were performed to understand the mechanisms whereby nicotine reduces l-DOPA-induced AIMs. We used a well established model of dyskinesias, l-DOPA-treated unilateral 6-hydroxydopamine-lesioned rats.
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LC/MS Characterization of Impurities and Degradation Products of a Potent Antitumor Peptidic Dimer, CU201
An HPLC method was developed, as part of a study supported by the National Cancer Institute's (NCI's) Rapid Access to Interventional Development (RAID) program, to assess the purity and stability…
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T2 Relaxation Times of 13C Metabolites in a Rat Hepatocellular Carcinoma Model Measured in Vivo Using 13C-MRS of Hyperpolarized [1-13C]Pyruvate
Following hyperpolarized [1-13C]pyruvate injections, pyruvate and its metabolic products, alanine and lactate, were observed in the liver of five rats with hepatocellular carcinoma and five healthy control rats.