Biomedical sciences publications
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Discovery of 1-[3-(4-Bromo-2-Methyl-2H-Pyrazol-3-Yl)-4-Methoxyphenyl]-3-(2, 4-Difluorophenyl)Urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia
We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep…
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Cytokine Measurements in a Mouse Vaginal Irritation Model for the Safety Evaluation of Microbicides
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MicroRNA Expression Differentiates Histology and Predicts Survival of Lung Cancer
We investigated whether microRNA (miR) expression profiles can differentiate histologic subtypes and predict survival for non–small cell lung cancer.
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Shewanella knowledgebase: integration of the experimental data and computational predictions suggests a biological role for transcription of intergenic regions
The Shewanella knowledgebase was established in 2005 to provide a framework for integrated genome-based studies on Shewanella ecophysiology.
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Binge Ethanol Treatment Is Insufficient to Elevate Cytokine Levels Measured in Rat Blood, Liver, and Brain
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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized By Abnormalities in PDGFRA, IDH1, EGFR, and NF1
We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.
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Synthesis and Tissue Distribution Studies of Acyloxyalkyl Prodrug Derivative of an Anti-HBV Dinucleotide
The preferential distribution of the dinucleotide 1 and its prodrug 2 into liver may be attributed to the presence of nucleoside phosphorothioate backbone because phosphorothioate oligonucleotides also reveal a similar…
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The Metal-Responsive Transcription Factor-1 Protein Is Elevated in Human Tumors
In the present study, we investigated MTF-1 protein expression in human tissues by specific immunostaining of both normal and tumor tissue samples.
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Disrupted Frontocerebellar Networks in Alcoholics Revealed By Resting State Functional Connectivity Imaging
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Disruption of Bottom-Up Processes in Alcoholics: Examination with Visuoperceptual Testing and Quantitative Fiber Tracking
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DEGAS: de novo discovery of dysregulated pathways in human diseases
While a pathway is usually defined as a set of genes known to share a specific function, pathway boundaries are frequently difficult to assign, and methods that rely on such…
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Diffusion MR Imaging in Neuropsychiatry and Aging
This chapter provides a review of diffusion imaging findings in normal aging and a sampling of neuropsychiatric diseases, and adds to a growing list of such overviews