Biomedical sciences publications
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The Use of Orthologous Sequences to Predict the Impact of Amino Acid Substitutions on Protein Function
We examined this assumption by evaluating a panel of nonsynonymous mutants of a prototypical human enzyme, methylenetetrahydrofolate reductase (MTHFR), in a yeast cell-based functional assay.
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Compensatory Anterior Frontal Slow Wave Activity in Recently Sober Alcoholic Men
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Using DNA Fingerprints to Infer Familial Relationships Within NHANES III Households
We inferred family relationships within households using DNA fingerprints (Identifiler®) that contain the DNA loci used by law enforcement agencies for forensic identification of individuals.
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Comparative Molecular Field Analysis of Fenoterol Derivatives: a Platform Towards Highly Selective and Effective Beta(2)-Adrenergic Receptor Agonists
We use a previously developed CoMFA model to design a series of new structures of high selectivity and efficacy towards the β2-adrenergic receptor.
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Lysosomal Degradation of Alpha-Synuclein in Vivo
In this study, lysosomal clearance of α-synuclein in vivo was indicated by the detection of α-synuclein in the lumen of lysosomes isolated from the mouse midbrain.
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Reduced Prefrontal Responsiveness to Alcohol Stimuli in Chronic Alcoholism
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Comprehensive Evaluation of Let-Dependence of Chromosome Aberrations After Particle Radiation Exposure in Vivo
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Distinguishing Methicillin-Resistant and Sensitive Staphylococcus Aureus Using Volatile Headspace Metabolites
This proof-of-concept study used solid-phase microextraction fibers (SPME) to collect headspace vapors from a methicillin sensitive Staphylococcus aureus (MSSA) and a methicillin-resistant Staphylococcus aureus (MRSA) strain grown in vitro in liquid growth medium.
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SU11248 (Sunitinib) Directly Inhibits the Activity of Mammalian 5′-AMP-Activated Protein Kinase (AMPK)
Here we report that the chemotherapeutic drug SU11248 (sunitinib) is at least as potent an inhibitor of AMPK as compound C, which is a commonly used experimental direct inhibitor of…
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Patterns of Gene Expression in the Ductus Arteriosus Are Related to Environmental and Genetic Risk Factors for Persistent Ductus Patency
Three independent risk factors are associated with patent ductus arteriosus that fail to close during prostaglandin inhibition.
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Alcohol’s Effects on Brain and Behavior
One main area of this research has focused on the neuropsychological sequelae of alcoholism, which has resulted in the description of a pattern of sparing and impairment that provided an…
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Biomimetic Actinide Chelators: an Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-Li(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)
A perspective on the preclinical development of two hydroxypyridonate actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), is presented. The chemical syntheses of both candidate compounds have been optimized for scale-up.