Biomedical sciences publications
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Distinguishing Methicillin-Resistant and Sensitive Staphylococcus Aureus Using Volatile Headspace Metabolites
This proof-of-concept study used solid-phase microextraction fibers (SPME) to collect headspace vapors from a methicillin sensitive Staphylococcus aureus (MSSA) and a methicillin-resistant Staphylococcus aureus (MRSA) strain grown in vitro in liquid growth medium.
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SU11248 (Sunitinib) Directly Inhibits the Activity of Mammalian 5′-AMP-Activated Protein Kinase (AMPK)
Here we report that the chemotherapeutic drug SU11248 (sunitinib) is at least as potent an inhibitor of AMPK as compound C, which is a commonly used experimental direct inhibitor of…
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Patterns of Gene Expression in the Ductus Arteriosus Are Related to Environmental and Genetic Risk Factors for Persistent Ductus Patency
Three independent risk factors are associated with patent ductus arteriosus that fail to close during prostaglandin inhibition.
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Alcohol’s Effects on Brain and Behavior
One main area of this research has focused on the neuropsychological sequelae of alcoholism, which has resulted in the description of a pattern of sparing and impairment that provided an…
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Biomimetic Actinide Chelators: an Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-Li(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)
A perspective on the preclinical development of two hydroxypyridonate actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), is presented. The chemical syntheses of both candidate compounds have been optimized for scale-up.
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Do Evoked Potential Differences Reflect a Deficit in Those Suffering a Sleep Disorder, or Resilience in Those Who Can Avoid It?
The novel approach taken by Gumenyuk and colleagues in this issue of SLEEP1 has produced interesting and novel data about SWSD, specifically, the absence of a difference in N1, the appearance…
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Graded Brain Abnormalities in Alcoholics with and Without Signs of Wernicke Encephalopathy
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Pontocerebellar Volume Deficits and Ataxia in Alcoholic Men and Women: No Evidence for “Telescoping”
Whether women are more vulnerable to brain dysmorphology than men despite lower alcohol consumption levels or shorter dependency remains controversial and has not been considered with respect to infratentorial structures…
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Time-Frequency Analysis of Visual and Auditory Nogo Event Related Potentials in Alcoholic Women
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Trypanosoma Cruzi-Induced Activation of Functionally Distinct Alpha Beta and Gamma Delta CD4(-) CD8(-) T Cells in Individuals with Polar Forms of Chagas’ Disease
In this work, we sought to investigate whether αβ or γδ DN T cells display distinct immunoregulatory potentials in patients with polar forms of human Chagas' disease.
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Hyperpolarized (13)C MRSI for Therapeutic Response Monitoring of Prostate Cancer to Radiotherapy
In this technique, the transient fate of pyr and its downstream metabolites lactate (lac), alanine, and bicarbonate is measured with 13C Magnetic Resonance Spectroscopy Imaging (MRSI) following an injection of hyperpolarized…
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In Situ Chemical Analyses By Underwater Mass Spectrometry