Biomedical sciences publications

We examined this assumption by evaluating a panel of nonsynonymous mutants of a prototypical human enzyme, methylenetetrahydrofolate reductase (MTHFR), in a yeast cell-based functional assay.

We inferred family relationships within households using DNA fingerprints (Identifiler®) that contain the DNA loci used by law enforcement agencies for forensic identification of individuals.

In this study, lysosomal clearance of α-synuclein in vivo was indicated by the detection of α-synuclein in the lumen of lysosomes isolated from the mouse midbrain.

We use a previously developed CoMFA model to design a series of new structures of high selectivity and efficacy towards the β2-adrenergic receptor. 

This proof-of-concept study used solid-phase microextraction fibers (SPME) to collect headspace vapors from a methicillin sensitive Staphylococcus aureus (MSSA) and a methicillin-resistant Staphylococcus aureus (MRSA) strain grown in vitro in liquid growth medium.

Here we report that the chemotherapeutic drug SU11248 (sunitinib) is at least as potent an inhibitor of AMPK as compound C, which is a commonly used experimental direct inhibitor of…

Using in vitro and xenograft MCF-7 breast cancer models, we demonstrated that SR16157 inhibited STS activity, cell growth, and estrogenic functions and that SR16137 reduced expression of estrogen-regulated genes with greater potency…

This study used ethnographic methods to examine the perception of mercury contamination by adolescents in the mining community of Poconé, Mato Grosso, Brazil.

Visuospatial construction ability as used in drawing complex figures is commonly impaired in chronic alcoholics, but memory for such information can be enhanced by use of a holistic drawing strategy…