Biomedical sciences publications
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Bright Lights, Clearly Visible in the Healthcare R&D Tunnel, Could Burn Out for Lack of Funds
The promise of continued healthcare innovation is increasingly threatened by inadequate funding of R&D at many levels: in academic and nonprofit organizations, in small business ventures, and even in large…
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Geo-Based Aerial Surveillance Video Processing for Scene Understanding and Object Tracking
This paper presents an approach to extract semantic layers from aerial surveillance videos for scene understanding and object tracking.
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In Vivo Glutamate Decline Associated with Kainic Acid-Induced Status Epilepticus
Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus.
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Alcohol Consumption and Lung Cancer Risk in the Environment and Genetics in Lung Cancer Etiology (Eagle) Study
The authors investigated the relation between alcohol consumption and lung cancer risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study, a population-based case-control study.
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Effect of Aedes Aegypti Saliva on Macrophage Cytokine Expression and on Dengue Infection
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Alpha-Synuclein-Glucocerebrosidase Interactions in Pharmacological Gaucher Models: a Biological Link Between Gaucher Disease and Parkinsonism
The aim of this study was to determine whether there is a relationship between alpha-synuclein (α-syn), a key protein in Parkinson's disease pathogenesis, and abnormalities in glucocerebroside (GC) catabolism that…
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Oxygen-Induced Tension in the Sheep Ductus Arteriosus: Effects of Gestationon Potassium and Calcium Channel Regulation
We used isolated fetal sheep ductus arteriosus (pretreated with inhibitors of prostaglandin and nitric oxide production) to determine whether changes in K+- and CaL-channel activity could account for the developmental…
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Protein Expression Is Altered During Spontaneous Sleep in Aged Sprague Dawley Rats
Age-related changes in brain function include those affecting learning, memory, and sleep-wakefulness. Sleep-wakefulness is an essential behavior that results from the interaction of multiple brain regions, peptides, and neurotransmitters.
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Biodistribution, Toxicity and Radiation Dosimetry Studies of the Serotonin Transporter Radioligand 4-[18F]-ADAM in Rats and Monkeys
4-[18F]-ADAM is a potent serotonin transport imaging agent. We studied its toxicity in rats and radiation dosimetry in monkeys before human studies are undertaken.
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Impact of Alcoholism on Sleep Architecture and EEG Power Spectra in Men and Women
We aimed to determine the impact of alcoholism on sleep architecture and sleep EEG power spectra in men and women with uncomplicated alcoholism.
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Parallel Interhemispheric Processing in Hemineglect: Relation to Visual Field Defects
To study whether unconscious parallel processing depends on visual functional integrity, we compared the performance of neglect patients with visual field defects (VFDs) (n = 11) and hemianopic patients with partial or complete blindness…
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Effects of Ramelteon and Triazolam in a Mouse Genetic Model of Early Morning Awakenings
We test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runner mice.