Biomedical sciences publications

To study whether unconscious parallel processing depends on visual functional integrity, we compared the performance of neglect patients with visual field defects (VFDs) (n = 11) and hemianopic patients with partial or complete blindness…

4-[18F]-ADAM is a potent serotonin transport imaging agent. We studied its toxicity in rats and radiation dosimetry in monkeys before human studies are undertaken.

We aimed to determine the impact of alcoholism on sleep architecture and sleep EEG power spectra in men and women with uncomplicated alcoholism.

We sought to determine whether the wake-promoting effect of hypocretin changes with age in Wistar rats, a strain in which age-related changes in both sleep and hypocretin signaling have been…

SR13668 showed promising anti-cancer activity, however, it exhibited a very poor oral bioavailability. Therefore, a study was initiated to develop and evaluate formulations with a more favorable oral bioavailability.

This study explored associations of functional candidate gene polymorphisms with initial sensitivity to nicotine in 101 young adult nonsmokers of European ancestry.

To provide a perspective on NPO business models, 10 SRI case studies are summarized herein, including basic and contract research, discovery of new drugs and biologics, pharmaceutical and biotech R&D…

Quantitative fiber tracking derived from diffusion tensor imaging (DTI) was used to determine whether white matter association, projection, or commissural tracts are affected in nondemented individuals with HIV infection and to identify…

Sway and tremor abnormalities and the selective relations between greater sway and 5 Hz to 7 Hz tremor and smaller volumes of the anterior vermis had not heretofore been described…

We hypothesized that NOPr agonists, with bifunctional activity at the μ-opioid receptor (MOPr), may function as nonaddicting analgesics or as drug abuse medications.

The purpose of this study was to develop albumin–chitosan mixed matrix microsphere-filled coated capsule formulations of Typhoid Vi® antigen and to determine whether it can induce antigen-specific mucosal and systemic immune…