Biomedical sciences publications
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Working and Episodic Memory in HIV Infection, Alcoholism, and Their Comorbidity: Baseline and 1-Year Follow-Up Examinations
Selective memory deficits occur in individuals with human immunodeficiency virus (HIV) infection and those with chronic alcoholism, but the potential compounded effect of these conditions is seldom considered, despite the…
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The Impact of Alcoholism on Sleep Evoked Delta Frequency Responses
The KC incidence and amplitude were negatively impacted in alcoholic men and women with exacerbation of the normal aging effects, particularly over frontal scalp regions.
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Dopamine and Opioid Gene Variants Are Associated with Increased Smoking Reward and Reinforcement Owing to Negative Mood
We explored associations of gene variants in the dopamine, opioid, and serotonin pathways with smoking reward (‘liking’) and reinforcement (latency to first puff and total puffs) as a function of negative mood…
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Dopamine Genes and Nicotine Dependence in Treatment-Seeking and Community Smokers
We utilized a cohort of treatment-seeking white cigarette smokers to rank candidate gene single nucleotide polymorphisms associated with the Fagerström Test for Nicotine Dependence.
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Tools for Planning and Coordinating Development of Medical Countermeasures in the Public Sector
We have developed a set of software tools and methods for using them that could support the desired coordination and that could also provide for more rapid, comprehensive, and shared…
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Visuoconstructional Accuracy, Organizational Strategy, and Memory for a Complex Figure in Abstinent Alcoholics: Relation to Fiber Tract Integrity
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The Basics of Preclinical Drug Development for Neurodegenerative Disease Indications
Preclinical development encompasses the activities that link drug discovery in the laboratory to initiation of human clinical trials.
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Heterogeneity of Brain Dysmorphology in Human Alcoholism: Us-France Collaborative Project
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Accelerating Botulism Therapeutic Product Development in the Department of Defense
To mitigate the challenges of small-molecule drug discovery research efforts for the treatment of botulism, we propose product development tools to assist in management of the BoNT portfolio and to…
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Relevance of Iron Deposition in Deep Gray Matter Brain Structures to Cognitive and Motor Performance in Healthy Elderly Men and Women: Exploratory Findings
We tested functional correlates of an MR-based iron index in 10 healthy, elderly individuals previously reported to have a higher iron burden in the putamen and lower in the thalamus…
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Impact of Symptoms Experienced By Varenicline Users on Tobacco Treatment in a Real World Setting
This article examines reported symptoms, nonsmoking rates, and medication use among 1,018 smokers using varenicline in a randomized trial comparing three forms of behavioral support for smoking cessation (phone, Web,…
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Development of Medical Countermeasures for Biodefense: How Far Have We Come in Seven Years?