Biomedical sciences publications
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Tools for Planning and Coordinating Development of Medical Countermeasures in the Public Sector
We have developed a set of software tools and methods for using them that could support the desired coordination and that could also provide for more rapid, comprehensive, and shared…
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Visuoconstructional Accuracy, Organizational Strategy, and Memory for a Complex Figure in Abstinent Alcoholics: Relation to Fiber Tract Integrity
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The Basics of Preclinical Drug Development for Neurodegenerative Disease Indications
Preclinical development encompasses the activities that link drug discovery in the laboratory to initiation of human clinical trials.
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Heterogeneity of Brain Dysmorphology in Human Alcoholism: Us-France Collaborative Project
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Accelerating Botulism Therapeutic Product Development in the Department of Defense
To mitigate the challenges of small-molecule drug discovery research efforts for the treatment of botulism, we propose product development tools to assist in management of the BoNT portfolio and to…
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Relevance of Iron Deposition in Deep Gray Matter Brain Structures to Cognitive and Motor Performance in Healthy Elderly Men and Women: Exploratory Findings
We tested functional correlates of an MR-based iron index in 10 healthy, elderly individuals previously reported to have a higher iron burden in the putamen and lower in the thalamus…
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Impact of Symptoms Experienced By Varenicline Users on Tobacco Treatment in a Real World Setting
This article examines reported symptoms, nonsmoking rates, and medication use among 1,018 smokers using varenicline in a randomized trial comparing three forms of behavioral support for smoking cessation (phone, Web,…
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Genetic and Environmental Influences on the Ratio of 3’Hydroxycotinine to Cotinine in Plasma and Urine
This analysis sought to conduct a combined genetic epidemiologic and pharmacogenetic investigation of the 3HC/COT ratio in plasma and urine.
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Postural Sway Reduction in Aging Men and Women: Relation to Brain Structure, Cognitive Status, and Stabilizing Factors
This quantitative physiological and MRI study of sex differences across the adult age range examined the association between components of postural control and the integrity of brain structure and function…
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Activity of New NOP Receptor Ligands in a Rat Peripheral Mononeuropathy Model: Potentiation of Morphine Anti-Allodynic Activity by NOP Receptor Antagonists
The effect of new NOP receptor agonists and antagonists in the rat chronic constriction injury model was investigated.
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Impact of X Chromosome Genes in Explaining the Excess Risk of Cancer in Males
The authors examined cancer incidence sex ratios in Denmark for 1943–2003 by age group. At nongenital/nonbreast sites, incidences were consistently higher in males.
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Modulation of Luciferase Activity Using High Intensity Focused Ultrasound in Combination with Bioluminescence Imaging, Magnetic Resonance Imaging and Histological Analysis in Muscle Tissue
This study investigates the effect of high intensity focused ultrasound (HIFU) to muscle tissue transfected with a luciferase reporter gene under the control of a CMV-promoter.