Biomedical sciences publications
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Pharmacokinetics of Nikkomycin Z After Single Rising Oral Doses
Nikkomycin Z is an antifungal drug that inhibits chitin synthase. This agent is under development as an orphan product for treatment of coccidioidomycosis.
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Simultaneous Quantification of Perfusion and Permeability in the Prostate Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging with an Inversion-Prepared Dual-Contrast Sequence
The aim of the present study was to quantify both perfusion and extravasation in the prostate to discriminate tumor from healthy tissue, which might be achieved by dynamic contrast-enhanced magnetic…
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Degradation of Association and Projection White Matter Systems in Alcoholism Detected with Quantitative Fiber Tracking
Alcoholism affected FA and diffusivity, particularly λT, of several fiber bundles. Frontal and superior sites (frontal forceps, internal and external capsules, fornix, and superior cingulate and longitudinal fasciculi) showed greatest…
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Development of a Transillumination Infrared Modality for Differential Vasoactive Optical Imaging
We present the development and implementation of a new near infrared transillumination imaging modality for tissue imaging. Exogenous inhaled hyperoxic and hypercarbic gases are used as "vasoactive contrast agents" via…
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Integrated Analysis of Breast Cancer Cell Lines Reveals Unique Signaling Pathways
We mapped genomic, transcriptional and proteomic profiles for 30 breast cancer cell lines onto a curated Pathway Logic symbolic systems model of EgfR-MAPK signaling.
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Postnatal Estradiol Up-Regulates Lung Nitric Oxide Synthases and Improves Lung Function in Bronchopulmonary Dysplasia
Fetal estradiol levels increase during late gestation and estradiol up-regulates NOS, suggesting that after preterm birth estradiol deprivation causes attenuated lung NOS resulting in impaired pulmonary function.
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The Leukocytes Expressing DARPP-32 are Reduced in Patients with Schizophrenia and Bipolar Disorder
Bipolar disorder (BPD) and schizophrenia (SCZ) are severe disorders representing an enormous social, familiar and individual burden, being SCZ the most disabling psychiatric disorder characterized by psychosis and cognitive impairment.
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Selective Loss of Gabab Receptors in Orexin-Producing Neurons Results in Disrupted Sleep/Wakefulness Architecture
Here we analyze the in vivo and in vitro phenotype of mice lacking the GABAB1 gene specifically in orexin neurons (oxGKO mice) and demonstrate that GABAB receptors on orexin neurons are essential in stabilizing and consolidating sleep/wake…
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Expression of Neuronal Calcium Sensor-1 (NCS-1) is Decreased in Leukocytes of Schizophrenia and Bipolar Disorder Patients
We sought to investigate the NCS-1 expression in lymphocytes and monocytes (CD4+ T lymphocytes, CD56+ NK cells, CD19+ B lymphocytes and CD14+ monocytes) of SCZ and BPD patients.
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Chronic in Utero Cyclooxygenase Inhibition Alters PGE2-Regulated Ductus Arteriosus Contractile Pathways and Prevents Postnatal Closure
We used fetal mice and sheep to determine whether PGE2 has a role in the development of ductus contractility that is distinct from its function as a vasodilator.
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Pathway Analysis By Adaptive Combination of P-Values
Building upon existing P-value combining methods, we propose a class of highly flexible pathway analysis approaches based on an adaptive rank truncated product statistic that can effectively combine evidence of associations…
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Thyrotropin-Releasing Hormone Increases Behavioral Arousal Through Modulation of Hypocretin/Orexin Neurons
In vitro electrophysiological studies showed that bath application of TRH caused concentration-dependent membrane depolarization, decreased input resistance, and increased firing rate of identified Hcrt neurons.