Biomedical sciences publications
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A tandem liquid chromatography and tandem mass spectrometry (LC/LC–MS/MS) technique to separate and quantify steroid isomers 11β-methyl-19-nortestosterone and testosterone
Here we describe a high-sensitivity LC/LC-MS/MS method that combines chiral chromatography and reverse-phase chromatography.
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Pharmacokinetics and Safety Studies in Rodent Models Support Development of EPICERTIN as a Novel Topical Wound-Healing Biologic for Ulcerative Colitis
This study established for the first time the pharmacokinetics, bioavailability, and acute safety of EPICERTIN in healthy and dextran sodium sulfate-induced colitic mice and healthy rats.
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Systemic Administration of the TLR7/8 Agonist Resiquimod (R848) to Mice Is Associated with Transient, In Vivo-Detectable Brain Swelling
Here, resiquimod (R848) was administered to mice to stimulate peripheral immune activation, and the effects on brain volumes and neurometabolites determined.
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Resilience to COVID-19: Socioeconomic Disadvantage Associated With Positive Caregiver–Youth Communication and Youth Preventative Actions
We utilized the longitudinal Adolescent Brain Cognitive Development Study to understand how family socioeconomic disadvantage relate to disease burden, family communication, and preventative responses to the pandemic.
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Enhancement of sensitivity and quantification quality in the LC-MS/MS measurement of large biomolecules with sum of MRM (SMRM)
We describe here an approach to boost detection sensitivity and expand dynamic range in the quantitation of large molecules while maintaining analytical specificity using summation of MRM (SMRM) transitions and…
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The Pandemic’s Toll on Young Adolescents: Prevention and Intervention Targets to Preserve Their Mental Health
This longitudinal study identifies young adolescents who are most vulnerable to the psychological toll of the pandemic and provides insights to inform strategies to help adolescents cope better in times…
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Multi-label, multi-domain learning identifies compounding effects of HIV and cognitive impairment
We designed a multi-label classifier that labels the structural magnetic resonance images (MRI) of individuals by their HIV and CI status via two binary variables.
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Parental Knowledge/Monitoring and Depressive Symptoms During Adolescence: Protective Factor or Spurious Association?
The goal of this study was to conduct a more rigorous test of whether knowledge/monitoring is causally related to depressive symptoms.
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Growth trajectories of cognitive and motor control in adolescence: How much is development and how much is practice?
Executive control continues to develop throughout adolescence and is vulnerable to alcohol use. Although longitudinal assessment is ideal for tracking executive function development and onset of alcohol use, prior testing…
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Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers
We developed a novel technology for screening and sequencing libraries of synthetic molecules of up to a billion compounds in size.
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Aging Accelerates Postural Instability in HIV Infection: Contributing Sensory Biomarkers
Whether aging with HIV accelerates age-related liability for postural instability and what sensory factors contribute to imbalance were examined in 227 PWH and 137 people living without HIV (PWoH), age…
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Neurobiology of Alcohol Dependence: Focus on Motivational Mechanisms
Recent research focusing on brain arousal, reward, and stress systems is accelerating our understanding of the components of alcohol dependence and contributing to the development of new treatment strategies.