Biomedical sciences publications
-
Evoked K-Complex Amplitude Is a Sensitive Marker of Adult Brain Aging
-
Adenosinergic and Dopaminergic Signaling as Targets for Wake-Promoting Therapeutics: Insights from Mouse Genetic Models
-
Neuroimaging of the Wernicke-Korsakoff Syndrome
Presented is the neuroradiological signature of acute Wernicke's encephalopathy (WE), derived from different types of magnetic resonance imaging (MRI) sequences.
-
Opioidergic Projections to Sleep-Active Neurons in the Ventrolateral Preoptic Nucleus
We hypothesized that the influence of opiates on sleep may be mediated, at least in part, by the ventrolateral preoptic nucleus (VLPO), a key cell group for producing behavioral sleep.
-
Global-Local Interference Is Related to Callosal Compromise in Alcoholism: a Behavior-DTI Association Study
We used a global–local paradigm to assess component processes of visuospatial ability and MR diffusion tensor imaging (DTI) to examine whether alcoholism-related microstructural degradation of the corpus callosum contributes to…
-
Rapid Alterations in Cortical Protein Profiles Underlie Spontaneous Sleep and Wake Bouts
Preliminary microarray analyses show that changes in behavioral state influence regional mRNA profiles; however, the impact of sleep on protein signatures is virtually unexplored. In these studies, cortical protein profiles…
-
Correlation of Population Parameters Leading to Power Differences in Association Studies with Population Stratification
We implemented a genetic model for population-based association studies with stratified samples and evaluated the impact on power with different genetic scenarios.
-
New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology
This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field.
-
Peptidomics of Cpefat/fat Mouse Brain Regions: Implications for Neuropeptide Processing
Quantitative peptidomics was used to compare levels of peptides in wild type (WT) and Cpefat/fat mice, which lack carboxypeptidase E (CPE) activity because of a point mutation.
-
Dopamine D2 Receptor Polymorphisms and Adenoma Recurrence in the Polyp Prevention Trial
We investigated the association between DRD2 genotype at these loci and the risk of colorectal adenoma recurrence in the Polyp Prevention Trial. Odds ratios (OR) and 95% confidence intervals (CI)…
-
Yeast Bioassay for Identification of Inositol Depleting Compounds
We show here that hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, ethylhexanoate, and methyloctanoate decrease intracellular inositol levels and increase the expression of INO1, the gene encoding myo-inositol-3-phosphate synthase…
-
A Pilot Evaluation of a Nasal Expiratory Resistance Device for the Treatment of Obstructive Sleep Apnea
The present pilot study tests the hypothesis that the application of expiratory resistance via a nasal valve device would improve breathing during sleep in subjects with OSA and in primary…