Biomedical sciences publications
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Detoxification of Molinate Sulfoxide: Comparison of Spontaneous and Enzmatic Glutathione Conjugation Using Human and Rat Liver Cytosol
This study compared the metabolic capability of rat and human liver cytosol to form a glutathione (GSH)-conjugated metabolite of molinate.
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17 Alpha-Estradiol: a Less-Feminizing Estrogen
A substantial number of studies report that 17β-estradiol (E2; estrogen), a potent endogenous feminizing hormone, is neuroprotective.
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In Vivo Evidence for Alcohol-Induced Neurochemical Changes in Rat Brain Without Protracted Withdrawal, Pronounced Thiamine Deficiency, or Severe Liver Damage
Longitudinal effects of alcohol on brain metabolites measured in basal ganglia with single-voxel MRS were investigated in sibling pairs of wild-type Wistar rats, with one rat per pair exposed to…
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Identification of a Population of Sleep-Active Cerebral Cortex Neurons
We have identified a population of cells in the cortex that is activated during sleep in three mammalian species. These cortical neurons are a subset of GABAergic interneurons that express…
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Reduced Parasympathetic Activity During Sleep in the Symptomatic Phase of Severe Premenstrual Syndrome
We investigated HRV during sleep, a state that is relatively free of external disruptions, in 9 women with severe PMS and 12 controls.
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Nutritional Stress Affects Mosquito Survival and Vector Competence for West Nile Virus
We evaluated the effect of different sucrose meals following a blood meal containing West Nile virus (WNV) on Culex pipiens pipiens survival, nutritional status, and susceptibility to viral infection and transmission.
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Cortical Processing of Respiratory Occlusion Stimuli in Children with Central Hypoventilation Syndrome
Cortical integration of afferent mechanical stimuli caused by respiratory loading or upper airway occlusion can be tested by measuring respiratory-related evoked potentials (RREPs). We hypothesized that patients with CHS would…
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Sleep Deprivation Effects on Circadian Clock Gene Expression in the Cerebral Cortex Parallel Electroencephalographic Differences Among Mouse Strains
Sleep deprivation (SD) results in increased electroencephalographic (EEG) delta power during subsequent non-rapid eye movement sleep (NREMS) and is associated with changes in the expression of circadian clock-related genes in…
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Ventricular Expansion After Alcohol Exposure By Vapor Chamber in Wistar Rats
Here, we tested the hypothesis that wild-type Wistar rats, exposed to vaporized alcohol ensuring higher BALs than typically achieved with voluntary consumption in rodents, would model MRI findings in the…
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Ventricular Expansion in Wild-Type Wistar Rats After Alcohol Exposure By Vapor Chamber
Here, we tested the hypothesis that wild-type Wistar rats, exposed to vaporized alcohol ensuring higher BALs than typically achieved with voluntary consumption in rodents, would model MRI findings in the…
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Hypocretin/Orexin and Nociceptin/Orphanin Fq Coordinately Regulate Analgesia in a Mouse Model of Stress-Induced Analgesia
Stress-induced analgesia (SIA) is a key component of the defensive behavioral “fight-or-flight” response. Although the neural substrates of SIA are incompletely understood, previous studies have implicated the hypocretin/orexin (Hcrt) and…
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Shock Veins in L6 Chondrites and Constraints on the Impact History of the L6 Parent Body
In this study we use hydrodynamic calculations to explore possible impact conditions and sample locations on the L6 parent body for the highly shocked L6 chondrite RC106.