Biomedical sciences publications
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Nociceptin Attenuates Methamphetamine Abstinence-Induced Withdrawal-Like Behavior in Planarians
In the present study, we tested the hypothesis that abrupt discontinuation of methamphetamine would also cause withdrawal-like behavior in planarians and that the withdrawal-like behavior would be prevented by nociceptin,…
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Microarray Evaluation of the Listeria Monocytogenes Infection and Amoxicillin Treatment in Mice
By using Affymetrix Mouse Genome Arrays and biological replicates, the predictive value of liver and blood gene expression profiles previously identified was validated as predictive of Listeria monocytogenes infection severity.
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Effect of Sleep Stage on Breathing in Children with Central Hypoventilation
Given the differences in anatomy, physiology, and REM sleep distribution between infants and older children, and the reduced number of limb movements during REM sleep, we hypothesized that older subjects…
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Mitochondrial DNA Content: Its Genetic Heritability and Association with Renal Cell Carcinoma
The extent to which mitochondrial DNA (mtDNA) content (also termed mtDNA copy number) in normal human cells is influenced by genetic factors has yet to be established. In addition, whether…
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Ibuprofen-Induced Patent Ductus Arteriosus Closure: Physiologic, Histologic, and Biochemical Effects on the Premature Lung
The goal was to study the pulmonary, biochemical, and morphologic effects of a persistent patent ductus arteriosus in a preterm baboon model of bronchopulmonary dysplasia.
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Towards Digital Representation of Drosophila Embryogenesis
Using Drosophila embryogenesis as a model we are developing molecular, imaging and image analysis techniques to record an entire developmental system at cellular resolution.
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Gene Expression in the Rat Brain During Prostaglandin D2 and Adenosinergically-Induced Sleep
We compared gene expression in the cerebral cortex, basal forebrain, and hypothalamus during PGD2-induced and adenosinergically-induced sleep to results from our previously published study of recovery sleep (RS) after sleep…
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Diffusion Tensor Imaging of Deep Gray Matter Brain Structures: Effects of Age and Iron Concentration
Diffusion tensor imaging (DTI) of the brain has become a mainstay in the study of normal aging of white matter, and only recently has attention turned to the use of DTI…
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Expression, Activity, and Function of Phosphodiesterases in the Mature and Immature Ductus Arteriosus
We used ductus from immature (n = 25) and mature (n = 21) fetal sheep to investigate whether a developmental increase in PDE activity could explain the diminished cAMP accumulation that follows…
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Near-Infrared Fluorescent Labeling of Tissue Transglutaminase Substrates for Imaging Tumor Boundaries
A novel strategy is developed to optically image tumor boundaries by cross-linking near-infrared fluorescent-labeled tissue transglutaminase substrates into tumor boundary tissue.
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Fetal Thermal Effects of Diagnostic Ultrasound
Available evidence, experimental or epidemiologic, is insufficient to conclude that there is a causal relationship between obstetric diagnostic ultrasound exposure and obvious adverse thermal effects to the fetus.
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Advances in Pediatric Minimal Access Therapy: a Cautious Journey from Therapeutic Endoscopy to Transluminal Surgery Based on the Adult Experience
This article explores the confluence of pediatric minimal access surgery and therapeutic endoscopy in a novel modality called transluminal surgery, or NOTES.