Biomedical sciences publications
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Differential Expression of Clock-Related Genes in the Cerebral Cortex of Inbred Mouse Strains in Response to Sleep Deprivation
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Selective 5HT2A and 5HT6 Receptor Antagonists Promote Sleep in Rats
Serotonin (5-HT) has long been implicated in the control of sleep and wakefulness. This study evaluated the hypnotic efficacy of the 5-HT6 antagonist RO4368554 (RO) and the 5-HT2A receptor antagonist MDL100907 (MDL)…
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Preclinical Development of Neuropeptide Therapeutics and Diagnostics
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The Use of a Nasal Resistance Valve to Treat Sleep Disordered Breathing
The present pilot study tests the hypothesis that the application of expiratory resistance via a nasal valve device would improve breathing during sleep in subjects with OSA and in primary…
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Disruption of Top-Down and Bottom-Up Processes in Alcoholics: a Functional Magnetic Resonance Imaging Study
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Genetic and Environmental Influences on Nicotine Pharmacokinetic and Pharmacodynamic Phenotypes
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A Mouse Model for Familial Advanced Sleep Phase Syndrome
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Low Striatal Glutamate Levels Underlie Cognitive Decline in the Elderly: Evidence from in Vivo Molecular Spectroscopy
Here, we used a spectroscopic protocol, optimized for Glu detection, to examine the effect of age in 3 brain regions targeted by cortical efferents—the striatum, cerebellum, and pons—and to test…
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Who is to Blame if Snoring Becomes a Problem?
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Identification of Novel Cyp2A6*1B Variants: the Cyp2A6*1B Allele Is Associated with Faster in Vivo Nicotine Metabolism
We report evidence that CYP2A6*1B genotype is associated with faster nicotine clearance in vivo, which will be important to future CYP2A6 genotype association studies.
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Respiratory-Related Evoked Potentials During Sleep in Children
There have been no data on RREP during sleep in children. We thus examined children during sleep to determine whether early RREP components would be maintained during all sleep.
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AMP-Activated Protein Kinase Inhibits Transforming Growth Factor-Beta-Induced Smad3-Dependent Transcription and Myofibroblast Transdifferentiation
In wound healing, myofibroblast transdifferentiation (MFT) is a metaplastic change in phenotype producing profibrotic effector cells that secrete and remodel the extracellular matrix.