Biomedical sciences publications
-
Fe-Radiation-Induced Alterations in Circulating Leukocyte Populations in the Apoe Mouse Atherosclerosis Model Are Temporary
We irradiated ApoE mice with 56Fe focused to the aorta and carotids to determine how irradiation of the thymus with 56Fe affects circulating lymphocyte number, and ultimately to determine the…
-
Genetics of Nicotine Dependence and Pharmacotherapy
Despite significant strides in the understanding of the relative contribution of genetic and environmental factors to nicotine dependence and treatment, emergent challenges necessitate interdisciplinary coordinated effort for effective problem solving
-
Callosal Compromise Differentially Affects Conflict Processing and Attentional Allocation in Alcoholism, HIV, and Their Comorbidity
Diffusion tensor imaging was used to study the combined effects of HIV-infection and alcoholism (ALC) on corpus callosum (CC) integrity in relation to processes of attentional allocation and conflict resolution…
-
Effects of Saporin-Induced Lesions of Three Arousal Populations on Daily Levels of Sleep and Wake
Here, we directly test this hypothesis by a simultaneous triple lesion of these neurons using three saporin-conjugated neurotoxins.
-
Anti-Nociceptive and Anti-Allodynic Effects of a High Affinity NOP Hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in Rodents
Syn 1020, a NOP receptor directed peptide, administered systemically has anti-nociceptive activity in both acute and chronic pain models in mice and rats respectively.
-
SR 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice
We identified a novel nociceptin/orphanin FQ (NOP)/μ-opioid receptor agonist, SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], with high binding affinity and partial agonist activity at both receptors.
-
Advanced Patterns and Matches in Link Analysis
The Link Analysis Workbench (LAW) is a tool for detecting and monitoring situations of interest using inexact matching of graphical patterns.
-
The comprehensive updated regulatory network of Escherichia coli K-12
One hundred and fifty new interactions have been added to our databases as a result of this specific curation effort, in addition to those added as a result of our…
-
Software Supported Pattern Development in Intelligence Analysis
This paper describes the GEM pattern language for encoding analysts’ information needs in graphical patterns, and its use in the Link Analysis Workbench (LAW) system to find inexact matches to…
-
Issues in Algorithm Characterization for Link Analysis
In this paper, we outline techniques for modeling algorithms that allow a system architecture to reason about their behavior and performance, individually and in combination.
-
Execution Monitoring and Replanning with Incremental and Collaborative Scheduling
We describe the Flight Manager Assistant (FMA), a prototype system, designed to support real-time management of airlift operations at the USAF Air Mobility Command (AMC).
-
Angler: Collaboratively Expanding your Cognitive Horizon
The tool helps the group through the process of forming consensus, while preserving and quantifying differing ways of thinking. Angler provides a Web-based collaborative environment that allows users distributed by…