Biomedical sciences publications
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Epigenetic Alteration of the Wnt Inhibitory Factor-1 Promoter Occurs Early in the Carcinogenesis of Barrett’s Esophagus
We hypothesized that downregulation of the Wnt inhibitory factor-1 (WIF-1) might be involved in the neoplastic progression of Barrett's esophagus (BE).
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Regional Protein Expression During Spontaneous Sleep-Wakefulness
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Callosal Compromise Differentially Affects Conflict Processing and Attentional Allocation in Alcoholism, HIV, and Their Comorbidity
Diffusion tensor imaging was used to study the combined effects of HIV-infection and alcoholism (ALC) on corpus callosum (CC) integrity in relation to processes of attentional allocation and conflict resolution…
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Effects of Saporin-Induced Lesions of Three Arousal Populations on Daily Levels of Sleep and Wake
Here, we directly test this hypothesis by a simultaneous triple lesion of these neurons using three saporin-conjugated neurotoxins.
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Anti-Nociceptive and Anti-Allodynic Effects of a High Affinity NOP Hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in Rodents
Syn 1020, a NOP receptor directed peptide, administered systemically has anti-nociceptive activity in both acute and chronic pain models in mice and rats respectively.
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SR 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice
We identified a novel nociceptin/orphanin FQ (NOP)/μ-opioid receptor agonist, SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], with high binding affinity and partial agonist activity at both receptors.
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Issues in Algorithm Characterization for Link Analysis
In this paper, we outline techniques for modeling algorithms that allow a system architecture to reason about their behavior and performance, individually and in combination.
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Advanced Patterns and Matches in Link Analysis
The Link Analysis Workbench (LAW) is a tool for detecting and monitoring situations of interest using inexact matching of graphical patterns.
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The comprehensive updated regulatory network of Escherichia coli K-12
One hundred and fifty new interactions have been added to our databases as a result of this specific curation effort, in addition to those added as a result of our…
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Software Supported Pattern Development in Intelligence Analysis
This paper describes the GEM pattern language for encoding analysts’ information needs in graphical patterns, and its use in the Link Analysis Workbench (LAW) system to find inexact matches to…
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Supporting the Pattern Development Cycle in Intelligence Gathering
This paper discusses the cycle through a use case of the Link Analysis Workbench (LAW), a tool for discovering and analyzing situations of interest in large relational data sets.
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Execution Monitoring and Replanning with Incremental and Collaborative Scheduling
We describe the Flight Manager Assistant (FMA), a prototype system, designed to support real-time management of airlift operations at the USAF Air Mobility Command (AMC).