Publications
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Longitudinal Characterization of Diurnal Rhythms of Activity and Core Body Temperature in the zQ175 Knock-in Mouse Model of Huntington’s Disease: Genotype and Sex Interactions
These initial findings demonstrate that mutant huntington expression in this model causes progressive motor and thermoregulatory deficits with significant genotype and sex differences.
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Calibration of Membrane Inlet Mass Spectrometric Measurements of Dissolved Gases: Differences in the Responses of Polymer and Nano-Composite Membranes to Variations in Ionic Strength
This work examines the transmission behavior of aqueous dissolved methane, nitrogen, argon and carbon dioxide through two types of membranes: a polysiloxane nano-composite (PNC) membrane and a conventional polydimethylsiloxane (PDMS) membrane.
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A Regression Model for Risk Difference Estimation in Population-Based Case-Control Studies Clarifies Gender Differences in Lung Cancer Risk of Smokers and Never Smokers
Additive risk models are necessary for understanding the joint effects of exposures on individual and population disease risk. Yet technical challenges have limited the consideration of additive risk models in…
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Development of Powder-in-Bottle Formulation of Hydroxyurea with Methylparaben Preservative
The compatibility of hydroxyurea with excipients in closed cap conditions at 30°C/65%RH and 40°C/75%RH storage for up to 6 weeks was also studied.
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Evaluation of the First Year of the Oakland Blended Learning Pilot
With support from RFF, OUSD, and other external assistance providers, the goal of the pilot is to support teachers in Oakland schools as they worked to personalize learning through the…
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Sleep-Wake Regulation Is Altered in Mice Lacking Trace Amine-Associated Receptor 1
Here, we tested the hypothesis that endogenous TAAR1 tone contributes to the normal regulation of sleep and wakefulness. Abnormal levels of TAs have long been associated with neuropsychiatric disorders; altered…
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α4β2* and α7 Nicotinic Receptors Play a Role in L-Dopa-Induced Dyskinesias; Studies Using Parkinsonian Knockout Mice
Since α4a5β2 nAChRs are also predominantly on striatal dopamine terminals, these data suggest that drugs targeting α4β2 nAChRs may reduce L-dopa-induced dyskinesias in late stage Parkinson’s disease.
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Vagal Withdrawal During Hot Flashes Occurring in Undisturbed Sleep
Little is known about the impact of hot flashes on cardiac autonomic regulation, in particular vagal control. Thereby, we assessed the cardiac autonomic profile associated with physiological hot flashes occurring…
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Quality Measure Functions for Calibration of Speaker Recognition Systems in Various Duration Conditions
This paper investigates the effect of utterance duration to the calibration of a modern i-vector speaker recognition system with probabilistic linear discriminant analysis (PLDA) modeling.
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Autonomic Regulation across Phases of the Menstrual Cycle and Sleep Stages in Women with Premenstrual Syndrome and Healthy Controls
To investigate the influence of menstrual cycle phase and the presence of severe premenstrual symptoms on cardiac autonomic control during sleep, we performed heart rate variability (HRV) analysis.
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Imaging Hippocampal Neuronal Activity across Sleep/Wake States in Freely Behaving Mice
We have utilized a combination of methodologies that collectively enable time-lapse imaging of CA1 neuronal calcium dynamics in behaving mice over periods of many weeks.
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Recent Developments in Voice Biometrics: Robustness and High Accuracy
We highlight SRI’s innovations that resulted from the IARPA Biometrics Exploitation Science & Technology (BEST) and the DARPA Robust Automatic Transcription of Speech (RATS) programs, as well as SRI’s approach…