Publications
-
Folate Receptor Targeted Nanophosphors for Enhanced Tumor Radiotherapy
Here we present a folic acid (FA) conjugated nanophosphor (NP) intended to enhance the therapeutic effect of radiotherapy by augmenting the production of reactive oxygen species with simultaneous photodynamic therapy…
-
Learning to Ask the Right Questions
Asking questions can clarify concepts, test hypotheses, add missing information, or provide additional knowledge to facilitate learning. The last item motivates the work described in this paper.
-
Lysosomal Degradation of Alpha-Synuclein in Vivo
In this study, lysosomal clearance of α-synuclein in vivo was indicated by the detection of α-synuclein in the lumen of lysosomes isolated from the mouse midbrain.
-
Mendel: Efficiently Verifying the Lineage of Data Modified in Multiple Trust Domains
We describe Mendel, a protocol with a three-pronged strategy that combines eager signature verification, lazy trust establishment, and cryptographic ordering witnesses to yield fast lineage verification in distributed multi-domain environments.
-
Student Modeling In An Intelligent Tutoring System.
In this chapter we review and summarize some of the main studies we have done with the system. Our results are surprising- by providing tutoring to students while they are…
-
SU11248 (Sunitinib) Directly Inhibits the Activity of Mammalian 5′-AMP-Activated Protein Kinase (AMPK)
Here we report that the chemotherapeutic drug SU11248 (sunitinib) is at least as potent an inhibitor of AMPK as compound C, which is a commonly used experimental direct inhibitor of…
-
Assessing 21st Century Skills: Summary Of A Workshop
Pellegrino reflects on the need for substantial change in what we expect students to know and be able to do in science, how science should be taught, and how science…
-
Unraveling a Card Trick
The principle underlying the card trick can be proved in a number of ways. We present the argument as a series of transformations that demystify the trick and describe its…
-
Development of an Autonomous Sea Ice Tethered Buoy for the Study of Ocean-Atmosphere-Sea Ice-Snow Pack Interactions: the O-Buoy
A buoy based instrument platform (the "O-buoy") was designed, constructed, and field tested for year-round measurement of ozone, bromine monoxide, carbon dioxide, and meteorological variables over Arctic sea ice.
-
Efficient Querying of Distributed Provenance Stores
We are developing a completely decentralized system with each computer maintaining the authoritative repository of the provenance gathered on it.
-
Expanding 21st Century Science Learning to Encompass Civic Reasoning on Science Issues
We overview and illustrate the characteristics of civic reasoning. Then, we propose lines of research for identifying models of how distributed communities leverage cyber infrastructures in the pursuit of discourse…
-
Gibbs Sampling in Open-Universe Stochastic Languages
This paper goes some way to remedying this deficit by introducing, and proving correct, a generalization of Gibbs sampling to partial worlds with possibly varying model structure.