Publications
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Combinatorial Chemistry: Oh What a Decade or Two Can Do
This short commentary takes a stroll through the early days of the field of combinatorial chemistry and molecular diversity. It offers a high-level perspective on the field's beginnings--and its future--as…
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Expression of Neuronal Calcium Sensor-1 (NCS-1) is Decreased in Leukocytes of Schizophrenia and Bipolar Disorder Patients
We sought to investigate the NCS-1 expression in lymphocytes and monocytes (CD4+ T lymphocytes, CD56+ NK cells, CD19+ B lymphocytes and CD14+ monocytes) of SCZ and BPD patients.
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Integrated Analysis of Breast Cancer Cell Lines Reveals Unique Signaling Pathways
We mapped genomic, transcriptional and proteomic profiles for 30 breast cancer cell lines onto a curated Pathway Logic symbolic systems model of EgfR-MAPK signaling.
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Postnatal Estradiol Up-Regulates Lung Nitric Oxide Synthases and Improves Lung Function in Bronchopulmonary Dysplasia
Fetal estradiol levels increase during late gestation and estradiol up-regulates NOS, suggesting that after preterm birth estradiol deprivation causes attenuated lung NOS resulting in impaired pulmonary function.
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Observations of Polar Mesospheric Summer Echoes Using Pfisr During the Summer of 2007
The Poker Flat Incoherent Scatter Radar (PFISR) has been running nearly continuously throughout the summer of 2007, which permits an unprecedented, long-term study of polar mesospheric summer echoes (PMSE) at UHF.
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Pathway Analysis By Adaptive Combination of P-Values
Building upon existing P-value combining methods, we propose a class of highly flexible pathway analysis approaches based on an adaptive rank truncated product statistic that can effectively combine evidence of associations…
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Thyrotropin-Releasing Hormone Increases Behavioral Arousal Through Modulation of Hypocretin/Orexin Neurons
In vitro electrophysiological studies showed that bath application of TRH caused concentration-dependent membrane depolarization, decreased input resistance, and increased firing rate of identified Hcrt neurons.
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Case Studies of Aerosol Remote Sensing in the Vicinity of Clouds
In this paper, we describe aerosol observations collected near cloud edges by an airborne Sun photometer over dark ocean waters.
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Femtosecond Laser Photoionization Time-Of-Flight Mass Spectrometry of Nitro-Aromatic Explosives and Explosives Related Compounds
The ultrafast laser-induced photoionization and photodissociation processes of the nitroaromatic containing explosive and explosive related compounds have been investigated at three laser wavelengths and power densities using a time-of-flight mass…
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What Works, What We Think Works, and How It Can Work for You
This session will first provide an overview of our understanding of the What Works Clearinghouse (WWC) standards of evidence for determining the rigor and quality of research studies, and we…
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Iteration Learning By Demonstration
We present a domain-independent approach to iteration learning by demonstration based on a dataflow model of user actions.
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Selective Loss of Gabab Receptors in Orexin-Producing Neurons Results in Disrupted Sleep/Wakefulness Architecture
Here we analyze the in vivo and in vitro phenotype of mice lacking the GABAB1 gene specifically in orexin neurons (oxGKO mice) and demonstrate that GABAB receptors on orexin neurons are essential in stabilizing and consolidating sleep/wake…