Publications
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Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Groupon Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity
Abstract (E)-4-[3-(1-Adamantyl)-4′-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell-cycle arrest and apoptosis of leukemia and cancer cells. Studies demonstrated that 3-Cl-AHPC bound to the atypical orphan nuclear receptor small heterodimer partner (SHP).…
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In Vivo Evidence for Alcohol-Induced Neurochemical Changes in Rat Brain Without Protracted Withdrawal, Pronounced Thiamine Deficiency, or Severe Liver Damage
Longitudinal effects of alcohol on brain metabolites measured in basal ganglia with single-voxel MRS were investigated in sibling pairs of wild-type Wistar rats, with one rat per pair exposed to…
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17 Alpha-Estradiol: a Less-Feminizing Estrogen
A substantial number of studies report that 17β-estradiol (E2; estrogen), a potent endogenous feminizing hormone, is neuroprotective.
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Microfabricated Field Emitter Arrays for Electron and Ion Emission
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How Do We Certify for the Unexpected?
We propose that safety cases based on explicit goals, evidence, and argument provide a firmer foundation for assurance, and a framework within which it is possible to address the rare…
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Aspect shifts in Indo Aryan
We introduce supporting data from the history of Old and Middle Indo-Aryan languages, whose instantiation of this pattern has not been previously noted.
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Micro-fluidic-based optical detection platform for characterizing fluorescing objects with integrated wavelength detection
We describe a compact, low-cost analyte detection platform that combines a fluidic channel, large area fluorescence excitation and on chip wavelength detection.
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Uncertain luck and counterfactual stupidity
I argue that predicates of relative stupidity do have at-issue entailments, contra Barker 2002, based on evidence from their interaction with epistemic modals and with counterfactuals.
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Heuristic search for target-value path problem
In this paper, we introduce a new class of search problems in which the objective is to find a path whose total cost is as close as possible to a…
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Combining breadth-first and depth-first strategies in searching for optimal treewidth
This paper describes a new way to integrate the two strategies in a single search algorithm that combines the complementary strengths of both strategies to achieve significant speedups over either…
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Delegating capabilities in predicate encryption systems
We formally define delegation in predicate encryption systems and propose a new security definition for delegation.
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Capacity-delay tradeoff for information dissemination modalities in wireless networks
This paper presents the first comprehensive capacity-delay tradeoff study for random wireless ad hoc networks under all information dissemination modalities when nodes operate either with multi-packet reception (MPR) or single-packet…