Publications
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Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120
We are continuing our concerted effort to optimize our first lead entry antagonist, NBD-11021, which targets the Phe43 cavity of the HIV-1 envelope glycoprotein gp120, to improve antiviral potency and…
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Power-grid controller anomaly detection with enhanced temporal deep learning
Controllers of security-critical cyber-physical systems, like the power grid, are a very important class of computer systems. Attacks against the control code of a power-grid system, especially zero-day attacks, can…
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Evaluating Visual-Semantic Explanations using a Collaborative Image Guessing Game
Abstract While there have been many proposals on making AI algorithms explainable, few have attempted to evaluate the impact of AI-generated explanations on human performance in conducting human-AI collaborative tasks.…
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Next-Generation Spray Delivery of Vaccines and Other Therapeutics with High Viscosity Aerosol
While conventional methods for spraying (Spray 1.0) such as pump sprays are largely viscosity-limited and only work for fluids with consistency close to water, the PARC technology called FEA, short…
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How to train your speaker embedding extractor
In this study, we aim to explore some of the fundamental requirements for building a good speaker embeddings extractor. We analyze the impact of voice activity detection, types of degradation,…
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Approaches to multi-domain language recognition
Approaches found to provide robustness in multi-domain LID include a domain-and-language-weighted Gaussian backend classifier, duration-aware calibration, and a source normalized multi-resolution neural network backend.
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Voices Obscured in Complex Environmental Settings (VOiCES) corpus
This work is a multi-organizational effort led by SRI International and Lab41 with the intent to push forward state-of-the-art distant microphone approaches in signal processing and speech recognition.
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Ethical Considerations for AI Researchers
While the ethics of AI is not clear-cut, there are guidelines we can consider to minimize the harm we might introduce.
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Estimation of Graphlet Counts in Massive Networks
In this work, we propose an unbiased graphlet estimation framework that is (a) fast with significant speedups compared to the state-of- the-art, (b) parallel with nearly linear-speedups, (c) accurate with
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III-Nitride Lasers Challenges and Approaches to Expand the Emission Wavelength into the UV
In this tutorial talk we will review III-Nitride-based laser technology, discuss materials challenges using high band gap semiconductors, and present different approaches and tricks to overcome these barriers (i.e., polarization…
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The Evidence Based Curriculum Design Framework: Leveraging Diverse Perspectives in the Design Process
This paper describes our approach to integrating the learning sciences with best practices in app design: a design framework that involves researchers and developers in a co-development process to create…
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The impact of career and technical education on students with disabilities
We use multiple years of administrative data from Massachusetts to estimate the effect of participating in CTE on the academic outcomes of students with disabilities.