Publications
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Pharmacological Characterization of RO5461861, a Potent and Selective PDE10A Inhibitor
We describe the characterization of a new class of potent PDE10A inhibitors exemplified by 4-(Azetidine-1 -carbonyl)-2-methyl-2-H-pyrazole-3-carboxylic acid (2-phenylimidazo[1,2-a]pyrimidin-7-yl)-amide (RO5461861) in vitro as well as in behavioral tests relevant to NMDA-R…
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Towards community-centered support for peer-to-peer service exchange: rethinking the timebanking metaphor
We conducted a field study of the most prominent of these, timebanking; a system in which 'time dollars' are earned and spent by people providing services for and receiving them…
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Simulation, Design, Fabrication, and Testing of a Mems Resettable Circuit Breaker
We describe a novel concept for a microelectromechanical systems (MEMS) resettable circuit breaker. The concept involves fabricating the circuit breaker and the reset switch using a single microcantilever.
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School health services for children with special health care needs in California
This study attempted to determine how schools meet the direct service health needs of children and who provides those services.
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High-resolution, high-frequency wavelength shift detection of optical signals with low-cost, compact readouts
In this paper, its calibration and noise performance is demonstrated for high-resolution (up to 1.45 fm/vHz) acoustic emission (AE) detection of fast (up to 1 MHz) dynamic strain signals.
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Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression
Here, the comprehensive preclinical pharmacological profile of basimglurant is presented with a focus on its therapeutic potential for MDD and drug-like properties.
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AT-1001: A High-Affinity alpha3beta4 nAChR Ligand with Novel Nicotine-Suppressive Pharmacology
The aim of this study was to investigate the mechanism of action underlying the nicotine-suppressive effects of AT-1001.
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Detection of Demographics and Identity in Spontaneous Speech and Writing
This chapter focuses on the automatic identification of demographic traits and identity in both speech and writing.
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Enabling Smart Camera Networks with Smartphone Processors
Distributed smart cameras exploit smartphone processor performance in their node communication and video metadata exchange, allowing the network to collectively reason in interpreting the scene, generating alerts, and making decisions.
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Interaction between Reproductive Hormones and Physiological Sleep in Women
This study aimed to assess the interaction between physiological sleep and reproductive hormone measures in perimenopausal women.
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Reasoning About Interruption of Biological Processes
Our work is motivated by the vision of automated asking and answering of questions related to a biology textbook—a capability which requires application of abstract reasoning patterns.
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Channel and Noise Robustness of Articulatory Features in a Deep Neural Net Based Speech Recognition System
This work presents a deep neural network (DNN)—hidden Markov model (HMM) based acoustic model where articulatory features are used in addition to mel-frequency cepstral coefficients (MFCC) for the Aurora-4 speech recognition task.