Publications
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USP8 Regulates Mitophagy by Removing K6-Linked Ubiquitin Conjugates from Parkin
We report here that USP8/UBPY, a deubiquitinating enzyme not previously implicated in mitochondrial quality control, is critical for parkin-mediated mitophagy.
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Inconsistency Monitoring in a Large Scientific Knowledge Base
We describe our approach for inconsistency monitoring in a large biology KB.
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Modification of the Loss Cone for Energetic Particles
The optimal pitch angle which maximizes the penetration distance, along the magnetic field, of relativistic charged particles injected from the midplane of an axisymmetric field is investigated analytically and numerically.
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Radar Detectability Studies of Slow and Small Zodiacal Dust Cloud Particles. I. The Case of Arecibo 430 MHz Meteor Head Echo Observations
In this paper, we present a new methodology utilizing meteor head echo radar observations that aims to constrain the ZDC physical model by ground-based measurements.
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(R,S)-Ketamine Metabolites (R,S)-Norketamine and (2S,6S)-Hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression.
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Design and Testing of a Selectively Compliant Underactuated Hand
Motivated by the requirements of mobile manipulation, a compliant underactuated hand, capable of locking individual joints, has been developed.
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Evidence of Reporting Biases in Voxel-Based Morphometry (VBM) Studies of Psychiatric and Neurological Disorders
Objective: To evaluate whether biases may influence the findings of whole-brain structural imaging literature.
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The α7 nicotinic receptor agonist ABT-107 decreases L-Dopa-induced dyskinesias in parkinsonian monkeys
Since rodent studies also suggested an involvement of α7 nAChRs in LIDs, we tested the effect of the potent, selective α7 agonist ABT-107 [5-(6-[(3R)-1-azabicyclo[2.2.2]oct-3-yloxy] pyridazin-3-yl)-1H-indole].
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Blockade of α6* nAChR Reduces L-Dopa-Induced Dyskinesias; Studies Using Parkinsonian α6* nAChR Gain-of-Function Mice
To understand the mechanism through which α6β2* nAChRs regulate L-dopa-induced AIMs, we used gain-of-function α6* nAChR (α6L9’S) mice. This mutation results in enhanced sensitivity to nicotine/acetylcholine and prolonged receptor-mediated activity.
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Entity Centric Feature Pooling for Complex Event Detection
In this paper, we propose an entity centric region of interest detection and visual-semantic pooling scheme for complex event detection in YouTube-like videos.
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The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.
The finding that smoking is inversely correlated with Parkinson’s disease and that nicotine attenuates nigrostriatal damage in Parkinsonian animals supports the idea that nicotine may be neuroprotective.
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Pharmacokinetics and Dose-Range Finding Toxicity of a Novel Anti-HIV Active Integrase Inhibitor
This paper reports on the pharmacokinetics and toxicokinetics of compound 1 and the relevance of these findings with respect to further development of this integrase-targeted antiviral agent.