Publications
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Association of CHRNA5-A3-B4 SNP rs2036527 with Smoking Cessation Therapy Response in African-American Smokers
We investigated the association between CHRNA5-A3-B4 and smoking abstinence. The rs2056527(A) allele was associated with lower abstinence with active pharmacotherapy, or with nicotine gum alone but not significantly with bupropion.
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Expanding the Metabolite Mimic Approach to Identify Hits for Mycobacterium Tuberculosis
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Toward a Breathable Biomarker for Physiological Stress
We have developed preliminary laboratory data for formation of volatile aldehydes produced by oxidatation of amino acids found in ELF exposed to HOCl. Formation of HOCl, via oxidation of chloride…
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Polymer-Based Flexible Visuo-Haptic Display
We report a flexible visuo-haptic display that allows for interactive haptic feedback on the visual display. The visuo-haptic display is fabricated by integrating a dielectric elastomer (DE) based thin film…
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Template-Based Circuit Understanding
We propose a template-based approach that extracts a functional description for a low-level combinational circuit by showing it to be equivalent to a reference implementation, while synthesizing an appropriate mapping…
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Synthesis of Doxycycline-[(CD3)-C-13]
In this process, doxcycline was oxidized to the N-oxide using m-CPBA. The hydrochloride salt of the tertiary N-oxide was treated with Fe(0)/FeCl3 catalyst yielding the N-demethylated product.
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ICOS-Based Chimeric Antigen Receptors Program Bipolar Th17/Th1 Cells
Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence.
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Sleep/Wake Regulation and Cortical EEG Are Disturbed in the Neuroligin-3 Rat Model of Autism
This study demonstrates the presence of sleep/wake abnormalities in a model of ASD, consistent with the presence of sleep disruptions found in ASD. The observed decreases in NREM and increased…
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BaySci: A Partnership for Bay Area Science Education—August 2014 Evaluation Report
We examined how and to what degree science instruction changed in the classrooms of districts, schools, and individuals participating in BaySci programming. We sought evidence of changes in classroom practice,…
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Recent Advances in Computer-Aided Drug Design as Applied to Anti-Influenza Drug Discovery
Zanamivir (Relenza™) and oseltamivir (Tamiflu(®)) are two antiviral drugs currently recommended by the CDC for treating influenza. Both are examples of the successful application of structure-based drug design strategies.
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Cyanide Detoxification by Molybdenum Sulfur Complexes
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Role of Conjugate and Local Terminators for Ionospheric Dynamics at Arecibo
Using some recent Plasma drift data at Arecibo, we present evidences of Electric Field (E) changes induced by sunrise and sunset transitions at both local and conjugate regions.